I've just started with 1mg methylb12 and will probably start methylfolate soon. But I'm not sure how to tell if you are having "defeciency" symptoms according to Freddd (Which means you need to increase the dose from what I understand) The symptoms are all signs of anemia like muscle weakness and mental dysfunction. I have all of those to a major degree all the time. I used to have neuropathy also but no more. So how do we tell if it's something caused by the supplements or just the disease itself?