I have severe ME and started taking duloxetine when I was very ill and bedridden. I was so scared at the time I started shaking and couldn't stop so was prescribed it for anxiety. It was a lifesaver at the time. That was four years ago and although I'm still ill I thought it was time to at least try to reduce it. I still get the odd anxiety symptoms but only ever physical symptoms, not actual feelings of anxiety. Anyways for the past 2 months I have been trying to reduce it gradually and have had a lot of side effects - sore stomach, headache, insomnia etc but these have passed. The main problem is that my ME has got worse. I am confused whether this is a side effect that will go away or if its because I need the duloxetine. I have heard it helps with POTS which I have so maybe I do need it? I've had to increase the dose again as I am very limited as to what i can do and can't afford to get worse. I don't want to be on this stuff forever and the ME isn't going anywhere fast!! Has anyone else been through this?