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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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No, I take a lot of other things, though! Methylfolate, AB12, MB12, HB12, C and DHEA.@Learner1 Have you tried royal jelly for BH4?
Agreed.It's more than just replenishing BH4, its addressing the damage caused by increased peroxynitrites due to its depletion, reducing stress to the mitochondria, restoring mitochondrial membrane potential, etc.
Yes. I'm on a low carb/higher fat organic Paleo diet, and take NT Factor, a customized methylation support protocol, ubiquinol, and minerals customized to my needs. I also take PolyMVA.@Learner1 Does your program include elements discussed in this thread?
http://forums.phoenixrising.me/index.php?threads/reverse-mitochondrial-damage-101.28175/
Clinical usage of several classes of antibiotics is associated with moderate to severe side effects due to the promotion of mitochondrial dysfunction...
The CNS is extremely dependent on delivery of molecular oxygen for maintaining a required level of metabolic activity, as reflected by the high concentration of neuronal mitochondria. Thus, it is not surprising to find several distinct behavioral abnormalities conforming to established psychiatric criteria that are associated with antibiotic usage in humans...
The mitochondrion is an enslaved bacterium, normally producing significant amounts of ATP in comparison to glycolysis [13]....
Antibiotics that are supposed to target pathogens will also bind to mitochondria with high affinity and cause side effects [17]. An example of this is seen with minocycline. It inhibits ATP synthesis and calcium retention in the mitochondria of brain cells [18]. The commonality of these antibiotic-induced side-effects lead physicians to create a term for this phenomenon called antimicrobial-induced mania, or antibiomania, since it can occur in neural tissues due to higher metabolic rates [19–21]...
We and others propose that mitochondria dysfunction may be part of the core problem for abnormal behaviors induced by antibiotic treatment, e.g., depression, autism, etc. [16,22–27]. Dysfunctional mitochondria have recently become a center of interest in explaining mental disorders [28–33]...
Additional examples of mitochondrial dysfunction, which are antibiotic-induced, are extensive and not limited to psychiatric behavior....
Antibiotic-induced mitochondrial damage can be pronounced on neurons, as noted earlier for behavior, especially given their metabolism, which requires 20% of the oxygen entering the body...
Perhaps this is why the majority of ME/CFS patients do so poorly on antidepressants?
This antibiotic will ruin you.
Posted on March 18, 2017
https://mountainsandmustardseedssite.wordpress.com/2017/03/18/this-antibiotic-will-ruin-you/
In re: Fluoroquinolone antibiotics.
Jim Morrison was taking cocaine, and died of heart failureCardiovascular Mitochondrial Dysfunction Induced by Cocaine - Hindawi Related articles
Mar 26, 2017 - Volume 2017 (2017), Article ID 3034245, 15 pages ... The pathogenesis of the cardiovascular toxicity of cocaine use has been largely ... An important contribution of mitochondria in COC-induced OS and ROS production has ...