Hi everyone, I'm new here, but I've been suffering from fatigue for 19 years (since age 20) I'd like your input on drugs I should try. I've seen 10+ doctors over the years, and they've ruled out all the typical causes ie Lyme disease, Celiac, etc. Some of the results I've had below may also be helpful to others. Symptoms - most of which occur pretty randomly from day to day: tiredness - mild to extreme brain fog - mild to extreme depression - none to moderate sleep - 5-7 hours/night. I'm unable to nap diarreah - constant, for 19 years gut locks up at night, unless I sleep at an angle gut pain seems to correspond with back pain Abnormal Tests: high folate - a bit above the high threshold nothing else! History: Mononucleosis at age 7 Things that help: Nicotine - great for motivation and depression Provigil / Modafinil - good for alertness Caffeine - good for alertness Elavil / Amitriptyline - tiny doses good for sleep Flexeril - good for sleep Lunesta - good for sleep Carafate / Sucralfate - cured my chronic gut pain certain mega-dose probiotics - randomly cure diarreah for a couple days, then stop working Things that seem to have no effect: exercise - I've had this being both in shape and overweight 10+ different specialty diets Ritalin Piracetam, Choline, Inositol, RNA, TMG, Acetyl L-Carnitine, N-Acetyl Tyrosine CoQ10, Flaxseed Oil, Resveratrol, Acai Cholestyramine, Librax Ambien, Sonata Bad Drugs: Imodium - causes severe gut pain Zoloft / Sertraline - good for depression, but seems to have permanently destroyed my sex drive after 6 months off it Cymbalta / Duloxetine - dizziness, nausea, vomiting, but cured diarreah for 3 days afterward!