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Droxidopa combined with Carbidopa in drug studies phase 11

Discussion in 'Latest ME/CFS Research' started by hensue, Sep 16, 2011.

  1. hensue

    hensue Senior Member

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    As you all know I am not the sharpest tool in the shed. I just read Adrianne Dellwo on about.com fibromyalgia and chronic fatigue. She has an article about the drugs that are in phase 11 for chronic fatigue and fibromyalgia. What do you think about these studies?? Is this posted somewhere else??

    Here is another dumb question I take wellbutin sr does it have common actions or workings as droxidopa. What I am getting at is what is the difference? I know wellbutrin sr is an AD and droxidopa is for parkinsons disease.

    Thanks
    Hensue

    The drug will be named NORTHERA by Chelsea Therapeutics.
     
  2. In Vitro Infidelium

    In Vitro Infidelium Guest

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  3. hensue

    hensue Senior Member

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    my computer has a virus and I cannot open any links and tried copy and paste still would not open. So what is In Vitro saying??
     
  4. hensue

    hensue Senior Member

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    can someone message copies of them to me please.
    Thanks
    Susie

    I have taken wellbutrin Sr for over 15 years and it has helped my fatigue and pain. Trying to find out if it has some of the properties of droxidopa??
     
  5. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    "A correlation between increased norepinephrine concentration in the central nervous system (CNS) and a decrease in fibromyalgia pain has been suggested in clinical studies. Therefore, as a pro-drug of norepinephrine, droxidopa could potentially benefit fibromyalgia patients by reducing pain as a result of increasing CNS levels of norepinephrine. As this benefit is presumed to be a central effect, the addition of carbidopa, a peripheral DOPA decarboxylase (DDC) inhibitor, may favorably impact the drug's treatment profile. Carbidopa is utilized as a blocker of peripheral DDC, an enzyme required for the conversion of droxidopa into norepinephrine. Therefore, inhibition of peripheral DDC should result in a reduction of any side effects resulting from the peripheral production of norepinephrine, whilst allowing for increased central levels, and hence, increased centrally mediated benefits."

    Footnote: I took another drug that increased norepinephrine in the synapses (strattera) and my fibromyalgia mostly went away.

    Sushi
     
  6. hensue

    hensue Senior Member

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    Thanks Sushi

    Why did you quit taking srattera? I know you are on ldn has it helped the pain?
    I really appreciate you replying.

    Take care
    Susie
     
  7. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    I stopped strattera for many reasons: I had improved enough not to really need it, I don't like to take more drugs than absolutely necessary, it is expensive, and the fibro pain never came back. I don't take LDN for pain, but for general CFS symptoms. It gives me more stamina.

    Best,
    Sushi
     

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