I'm trying to find an explanation for why drinking coffee improves my sleep. I don't consider this a good thing, I'm not advocating drinking coffee to improve your sleep. My quick run down is this: Lots of pain and low grade depression since I was a teenager. Steadily got worse until an almost total meltdown in my late 30's Saw many doctors for about 12 years or so with no results 3 years ago I discovered the power of nutritious food, improved to about 75%, and left the doctors behind. Last fall I learned of methylation and got a bunch of tests done: HD methylation panel (low glutathione and SAM; high SAH, adenosine) Yasko UAA (low amino acids across the board) Yasko UTEE (nothing alarming) 23andme (MTHFR A1298C and some others but not an overly concerning panel) I've read that coffee can be a methyl doner but also raises adenosine so my first step to improve methylation was to quit drinking coffee. In doing so I have learned that I cannot sleep without it, especially if I eat nutritious food, my sleep is much better eating less nutritious foods. If I eat a small amount (1oz) beef liver and/or leafy greens (not drinking coffee) I cannot sleep well that night. I can sort of understand this because I'd say the B12 and folate are driving methylation and this is detox or startup symptoms. I can sleep decent while eating much more liver and leafy greens if I'm also drinking coffee. As an example, one day after I hadn't slept well for 3-4 days (without coffee) I was so frustrated I drank 3.5 cups of coffee at work...I slept 9 solid hours that night. Now that I'm attempting the Active B12 protocol this effect is even more pronounced. Anyone experience this? Or have an idea where I can look? Thanks p.s. Thanks for all the great information here; I'd be lost without it!