I wonder if your severe chest pain might have been pleurodynia (aka, Bornholm disease or "devil's grip"), which is typically caused by coxsackievirus B. Coxsackievirus B can also cause myocarditis, which also involves chest pain symptoms. As the virus that triggered my ME/CFS spread around my friends and family (around 30 people), it caused several sudden myocarditis/pericarditis-related heart attacks in the previously healthy, and two cases of chronic myocarditis/pericarditis. Coxsackievirus B is a highly underrated virus, that causes a lot of different health problems. It's strongly linked to type 1 diabetes. This virus should be put on the vaccine schedule. I've read that it would be very straightforward to create a coxsackievirus B vaccine (ie, there are no technical hurdles as there are with a HIV or EBV vaccine). Such a coxsackievirus B vaccine might dramatically lower the incidence of ME/CFS, diabetes, and heart attacks. Though from the ME/CFS perspective, the antiviral angle is not the only one that might yield results. The symptoms of ME/CFS may be routed in viral infection in many cases, but in addition, there may be upstream causes and mechanisms that are responsible for actually producing the various symptoms of ME/CFS. If those upstream mechanisms can be treated, then it might tackle the symptoms of ME/CFS even if it does not address the original viral cause. For example, this thread about the huge reduction in brain fog experienced by a couple of ME/CFS patients when taking ceftriaxone (Rocephin), a drug which elevates GLT-1 glutamate transporter expression and activity, and thereby clears excessive extracellular glutamate from the brain. Dr Cheney thinks excessive glutamate may be driving the cognitive symptoms of ME/CFS. This glutamate is generated by brain inflammation. I am looking into trying Rocephin or a similar glutamate-clearing drug called riluzole, to see if this improves my brain fog. This excess glutamate theory of the cognitive symptoms of ME/CFS in fact ties in with Michael VanElzakker's vagus nerve infection hypothesis in the following way: Vagus nerve infection ➤ causes release of cytokines IL-1β, TNF-α and IL-6 ➤ these stimulate the vagus nerve ➤ this triggers brain inflammation ➤ brain inflammation releases glutamate in the brain ➤ and this may underpin the cognitive symptoms of ME/CFS. So if we can intervene in the final stage of this hypothesized causal chain, it may treat at least the cognitive symptoms of ME/CFS. Glad you are getting benefit. I am myself always after the "holy grail" of a sustained improvement in my ME/CFS symptoms. Even a 10% – 15% improvement can make a big difference. A few years ago I was often bedbound one or two days a week; but now I almost never need to lie down during the day. I am assuming that the supplements and drugs I have been taking are responsible for this. But I am always on the lookout for the next drug or supplement that will give me another 15%.