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Dr. Pridgen's 9 different cocktail mix patents & research under Dr. Carol Duffy name

Discussion in 'Active Clinical Studies' started by lartista, Mar 25, 2014.

  1. lartista

    lartista Senior Member

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    1) Dr. Pridgen's had 9 cocktail mix patents are showing up all August 13, 2013:
    http://www.faqs.org/patents/app/20130203783

    http://www.faqs.org/patents/inventor/william-l-pridgen-tuscaloosa-us-1/
    I found Dr. Pridgen's 9 pending patents for his cocktail mixes!!!!!!
    1) VALACICLOVIR AND CELECOXIB COMBINATION
    2) VALACICLOVIR AND DICLOFENAC COMBINATION
    3) ACICLOVIR AND DICLOFENAC COMBINATION
    4) ACICLOVIR AND CELECOXIB COMBINATION
    5) FAMCICLOVIR AND DICLOFENAC COMBINATION
    6) ACICLOVIR AND MELOXICAM COMBINATION
    7) FAMCICLOVIR AND MELOXICAM COMBINATION
    8) VALACICLOVIR AND MELOXICAM COMBINATION
    9) ANTIVIRAL COMPOUND AND COX-2 INHIBITOR COMBINATION INCLUDING COMBINATION OF FAMCICLOVIR AND CELECOXIB


    2) Where the research results are NOT being found easily under Dr. Pridgen's name, studies are being found up his associate professor's name... Dr. Carol Duffy
    http://bsc.ua.edu/about/faculty-directory/carol-duffy/

    Carol Duffy received a Ph.D. in Microbiology from the University of Iowa in 2000 and completed her postdoctoral research at Cornell University. She was appointed Assistant Professor at the University of Alabama in 2007, and Associate Professor in 2013.

    Research Interests

    My research interests lie in elucidating the mechanisms used by herpes simplex virus type 1 (HSV-1) to replicate within its host. The herpesviruses have been co-evolving with their hosts for millions of years, and have consequently developed elaborate mechanisms for replication and evasion of their hosts’ defense systems. HSV-1 is a neurotropic herpesvirus that infects ~80% of young adults worldwide. Infection of its human host is initiated with a lytic infection of the mucosal epithelium and continues through invasion of the peripheral nervous system that usually leads to establishment of a reactivatable latent infection. On occasion, HSV-1 spreads to the central nervous system, causing the most common type of sporadic viral encephalitis seen in western countries. In addition, HSV-1 can infect the corneal epithelium, causing a disease known as herpes simplex keratitis that often results in vision damage.

    HSV-1 contains a structure unique to all herpesviruses called the tegument, which is composed of 20+ viral and cellular proteins packaged into virions between the capsid and envelope. Tegument proteins play a variety of roles in infection including the regulation of viral and host gene expression and the promotion of virus assembly and egress. Many tegument proteins are synthesized late in infection at the time of virus assembly. Upon infection, both the genome-containing capsid and the tegument proteins are released into the host cell. Thus tegument proteins can potentially exert their activities at both very early times prior to viral gene expression, and late times when they are produced in high amounts.

    Studies in my lab focus on determining the roles of the various tegument proteins during HSV-1 replication and the mechanisms by which those roles are carried out. To this end, we utilize techniques in genetics, molecular biology, cell biology, biochemistry, microscopy, genomics, and proteomics. HSV-1 provides an excellent research system due to its short replication cycle and ease of culture. In addition there are a large number of available mutant HSV-1 strains, and with the development of the HSV-1 Bacterial Artificial Chromosome system, new mutants are easily designed and generated.


    Selected Publications by Dr. Duffy
    Mbong EF, Woodley L, Dunkerley E, Schrimpf JE, Morrison LA, Duffy C. Deletion of the herpes simplex virus 1 UL49 gene results in mRNA and protein translation defects that are complemented by secondary mutations in UL41. J Virol. 2012 Nov;86(22):12351-61.

    Dewberry EJ, Dunkerley E, Duffy C. Purification of full-length VP22 from cells infected with HSV-1: A two-pronged approach for the solubilization and purification of viral proteins for use in biochemical studies. J Virol Methods. 2012 Aug;183(2):180-5.

    Mbong EF, Woodley L, Frost E, Baines JD, Duffy C. Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle. J Virol. 2012 Jun;86(12):7003-7.

    Duffy C, Mbong EF, Baines JD. VP22 of herpes simplex virus 1 promotes protein synthesis at late times in infection and accumulation of a subset of viral mRNAs at early times in infection. J Virol. 2009 Jan;83(2):1009-17.

    Duffy C, Lavail JH, Tauscher AN, Wills EG, Blaho JA, Baines JD. Characterization of a UL49-null mutant: VP22 of herpes simplex virus type 1 facilitates viral spread in cultured cells and the mouse cornea. J Virol. 2006 Sep;80(17):8664-75.
  2. minkeygirl

    minkeygirl Is Jim Jones alive and well on PR?

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    Left Coast
    Thanks. I am currently taking Acyclovir and Meloxicam. I hope there is a "translation" of this for the medically dense and cognitively impaired.
  3. lartista

    lartista Senior Member

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    Monkeygirl... how's it working? Who's your doctor? The pub med reports are there under her name... I have not had time to read then... but using a little mix of ideas... it could be possible... I took Valtrex and it was wonderful for my brain fog and balance... Lerner loves valtrex... so my guess is it is Valtrex with one other mentioned...
    Last edited: Mar 26, 2014
  4. minkeygirl

    minkeygirl Is Jim Jones alive and well on PR?

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    I've been on acyclovir for awhile. I had no idea about this study when I started back on 10 mgs Meloxicam today for a sciatic nerve problem. So no clue yet.
  5. lartista

    lartista Senior Member

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    I have not yet figured out which is the winning cocktail of the 9 he uploaded for patent... but I am trying to figure it out..
    maryb likes this.
  6. minkeygirl

    minkeygirl Is Jim Jones alive and well on PR?

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    I'm limited since I can't take Celebrex or Valtrex or Famvir.
  7. Jon_Tradicionali

    Jon_Tradicionali Senior Member

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    There's no way of finding out until the phase 2 results are published.

    Unless Pridgen has a mole in his midst...
  8. lartista

    lartista Senior Member

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    If you go into the attachments, you can on each page, you can see a lot more detail....
  9. Jon_Tradicionali

    Jon_Tradicionali Senior Member

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    Yeah I've done that. But I meant there's no way of knowing which combination and at which dosage is the correct one as there are 9 candidates.

    Anyway, I am very impressed at the work and time you've put in to gather this info.

    Thanks.
  10. Iquitos

    Iquitos Senior Member

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    I hope it's not #3, acyclovir and diclofenac. I have been taking acyclovir, and when I could get it, diclofenac with codiene. The combination has been very helpful but no means a cure.

    I recently stopped acyclovir to see if I maybe didn't need it anymore (doing Steven Bruhner's herbal antiviral protocol and medical marijiuana), but my back pain came back with a vengeance so I resumed using acyclovir. I'll stop the herbal prococol when I run out of those tinctures and will continue the medical marijuana which helps a lot with sleep, pain in my joints and muscle spasms.

    (I will be growing my own mmj soon; I live where it is legal now. When I get a "crop" I intend to try using the whole plant raw and making an herbal tincure of it, and maybe making cannabutter.)
  11. lartista

    lartista Senior Member

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    Iguitos, I live in CO and Italy... so pot is legal in Co though I don't use.. I copied this from another site:

    "The big difference between the three antiviral drugs for herpes (Zovirax - which is acyclovir, Famvir - with is famciclovir, and Valtrex - which is valacycovir) is how often you need to take them every day.
    Zovirax was the first antiviral available for herpes, and you needed to take it something like five times per day. It was effective, but the drug didn't stay in your system very long, so you needed to take it often.

    Famvir was next, and you needed to take it less often than Zovirax, but still more than once a day.
    Valtrex is advertised as "once-daily" Valtrex because they finally got the time-release stuff good enough that you only need to take it once per day."

    Though my specialist said Valtrex was better than Acyclovir for ME/CFS. I hate codeine. "but no means a cure."... your right... in our lifetime NO cure is expected... we are just dreaming for help, relief, quality of life with a little space for happiness... with ME/CFS. I use LDN for my pain and that fixed it just fine...
    Francesca
    Last edited by a moderator: Apr 6, 2014
    Iquitos likes this.
  12. Bob

    Bob

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    Just a point of interest: The HHV6 website says there are other drugs that are used as antivirals for HHV-6:
    http://hhv-6foundation.org/clinicians/hhv-6-treatment

    ganciclovir (Cytovene® IV) / Valganciclovir (Valcyte® ORAL).
    cidofovir (Vistide® IV)
    foscarnet (Foscavir® IV)
    Last edited: Mar 26, 2014
    SOC likes this.
  13. lartista

    lartista Senior Member

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    Thanks... but Pridgen supposedly got very impressive results with two drugs mixed together... I wish I knew which two... Francesca
    Iquitos likes this.
  14. maryb

    maryb iherb code TAK122

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    and also he's focusing on a/virals that target HSV
    Iquitos likes this.
  15. Hip

    Hip Senior Member

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    Excellent find, lartista!


    I think the following paragraph taken from Dr William Pridgen's patent is the most important and significant:


    The above paragraph indicates that Dr Pridgen's rationale for using a COX-2 inhibitor like celecoxib, diclofenac or meloxicam is not simply for anti-inflammatory purposes, but because COX-2 inhibitors dramatically inhibit herpes simplex I and II replication.

    Thus it would appear that Dr Pridgen has found that combining a regular herpes simplex antiviral (like acyclovir, valacyclovir or famciclovir) with a COX-2 inhibitor (like celecoxib, diclofenac or meloxicam) has a far greater antiviral effect against herpes simplex.

    Note in particular the Gebhardt study mentioned in the patent: this study found that COX-2 inhibitors can suppress stress-induced herpes simplex viral reactivation. Dr Pridgen believes that that in fibromyalgia, stressors, peptides and hormones released by the sympathetic nervous system and HPA axis promote HSV reactivation, and that repeated HSV reactivation kills the sensory nerve cells, and destroys part of the nerve ganglion. But COX-2 inhibitors specifically target and counter this stress-induced HSV reactivation.



    So there is no great mystery about Dr Pridgen's antiviral protocol. Judging by Pridgen's patents, I would think that all that's required to do this protocol are two drugs:

    A Herpes Simplex Antiviral
    choose either: acyclovir, valacyclovir or famciclovir
    +
    A COX-2 Inhibitor

    choose either: celecoxib, diclofenac or meloxicam​

    It is good to have various choices of drug, because people may experience bad side effects from one particular drug, but not from others, and so you need to choose a drug that works best for you. For example. I cannot tolerate valacyclovir very well, because it creates anxiety side effects in me, but I am fine with famciclovir.



    I wonder whether taking several natural COX-2 inhibitors together in combination might be almost as good as COX-2 inhibitor drugs like celecoxib? Potent natural COX-2 inhibitors include:

    Potent COX-2 Inhibitor Herbs:

    Rhodiola rosea 500 mg
    Curcumin 1000 mg
    Holy basil (tulsi) 1000 mg
    Bee propolis 1000 mg
    Terminalia chebula 1000 mg
    EGCG green tea extract 300 mg
    Boswellia serrata extract 300 mg​

    Potent COX-2 Inhibitor Essential Oils:

    Thyme essential oil
    Oregano essential oil​

    Less Potent Natural COX-2 Inhibitors:

    Sulforaphane 400 mcg, reishi 1000 mg, ginger 1000 mg, nettle 1000 mg, milk thistle 1000 mg, lemon balm 1000 mg, ashwagandha 1000 mg, American ginseng 500 mg, bromelain 500 GDU, feverfew 500 mg, quercetin 250 mg, berberine 50 mg, evening primrose oil 2000 mg, fish oil 1000 mg, skullcap 500 mg, selenium 100 mg, vitamin E (gamma-tocopherol form) 200 mg.​

    The slight problem with COX-2 inhibitors like celecoxib, diclofenac and meloxicam is that these NSAID drugs can cause some significant side effects; in particular, they can sometimes cause serious stomach and intestinal ulcers. So it might be safer to take say a combination of 5 or 6 of the above potent natural COX-2 inhibitors together, instead of a pharmaceutical COX-2 inhibitor. However, I don't know for sure that these natural COX-2 inhibitors will match the strength of the COX-2 inhibitor drugs.



    Note that COX-2 inhibitors not only display antiviral effects against herpes simplex I and II, but also against cytomegalovirus, and against H5N1 influenza virus (bird flu).
    Last edited: Apr 3, 2014
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  16. Jon_Tradicionali

    Jon_Tradicionali Senior Member

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    Considering you've researched the protocol and COX2, may I ask why YOU have yet to try it?

    If it works, it would achieve remission and I'm sure you'd be thrilled with that result.
  17. Hip

    Hip Senior Member

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    That is a suspicious stance!

    The answer to this question is because I just performed this research today, a few hours ago in fact, immediately after reading the patent information recently posted by lartista above.


    Though I have in fact tried COX-2 inhibiting supplements previously: around 3 or 4 years ago, I used to take a set of supplements including propolis, curcumin and 5-LOXIN to suppress COX-2, because I discovered this had an anti-anxiety effect, and I was suffering from severe anxiety at that point.
    Last edited: Apr 3, 2014
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  18. Jon_Tradicionali

    Jon_Tradicionali Senior Member

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    Hah

    I didn't intend it to come off as suspicious. Just curious.

    You address the reader (PR users) as 'you' when detailing the combo which could be effective for them. Yet you've only researched it yourself for a day.

    I'm sure you can understand where I am coming from.
  19. globalpilot

    globalpilot Senior Member

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    Nice work HIp. Just wondering, though, in light of Dr Montoyas recent statement that Valcyte is antiinflammatory, if the effect Pridgen is getting isn't really through inhibiting inflammation rather than antiviral.



  20. maryb

    maryb iherb code TAK122

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    @globalpilot
    Isn't Valcyte a totally different type of a/viral to the one/s used in this study though?

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