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Dr. Peterson's Testimony at the CFSAC in Text

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by Cort, Nov 26, 2009.

  1. Cort

    Cort Phoenix Rising Founder

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  2. dannybex

    dannybex Senior Member

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    Thanks Cort...

    This was news to me...

    "With XMRV it was important to differentiate it from all the other mouse retroviruses that are in the family of the gamma retroviruses. And this phylogenetic tree that was developed by gene-sequencing, demonstrated that this particular XMRV that we isolated from the Chronic fatigue patients was similar to, but not identical to, the XMRV that has been demonstrated in patients with prostate cancer..."

    For some reason I thought it was the same thing.

    And this was also surprising:

    "We did look at the genetic variation in RNASE-L that had been reported in the prostate cancer patients. Its a fairly common genetic abnormality in the population at large. And in fact we did not see any correlation with the patients who were positive. "

    Finally, the following seems to contradict what he told you after the conference:

    "And so you can generate a hypothesis much like the HIV hypothesis is that you get an acute infection, you develop an antibody response, ultimately you have a failure of the immune system and we postulate here that maybe in NK-cell numbers and function resulting in very significant and prolonged disease."

    Is my brain completely rotting, or didn't you say Cort that he believed a weakened immune system comes before XMRV infection?

    thanks,

    d-bex
  3. Cort

    Cort Phoenix Rising Founder

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    This

    Surprised me as well. Its really hard to figure out what's going on. Is it so similar to the XMRV in prostate cancer that they are essentially the same or is it different in significant ways?

    This brings up another interesting point. Apparently the genetic variation RNase L. that inhibits its activity is fairly common but what about the RNase L dysfunction found in many chronic fatigue syndrome patients? We have two different abnormalities here - both appear to inhibit RNase L functioning but probably n different ways and in different degrees. Now I'm not clear whether both RNase L. problem are not a factor in XMRV; perhaps the RNase L dysfunction in chronic fatigue syndrome does contribute to it.

    Yes, I was a bit surprised by that statement as well. I guess its all conjecture at this point whether the virus comes first or the immune dysfunction. He told me that his guess was that an immune weakness (plus other problems?) comes first but here suggested that the other could be true. Hopefully someday we'll know!
  4. Esther12

    Esther12 Senior Member

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    Arround the time of the initial announcement I remember virologists mentioning the differences with prostate-xmrv, and saying that the differences were very small, and indicative that the virus had probably moved to humans relatively recently (within the last century or so).

    All with the usual provisos about this being very preliminary guess-work.
  5. garcia

    garcia Aristocrat Extraordinaire

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    The value of having the transcripts is that we can answer questions like this. From Dr Coffin's testimony (yet to be posted):
    In other words all these various strains isolated so far from prostate cancer & CFS are the same virus, XMRV, but with minor variations (as you would expect in a mutating virus). And actually as Dr Coffin says the most distant pair are both from prostate cancer. So its not like there is one strain in prostate cancer, and one strain in CFS. There are lots of strains across both diseases, but you can't necessarily separate the strains by disease. If you could easily seperate the strains by disease then the most distant pair would be one from CFS and one from Prostate Cancer.

    Dr Coffin goes on to say:

  6. starryeyes

    starryeyes Senior Member

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    Thanks for the explanations about the differences found in XMRV in Prostate Cancer vs CFS, garcia and Esther. I have been wondering about this and got answers here many weeks ago but forgot the particulars that were in the replies.

    garcia it's great to have Dr. Peterson's testimony in written format. I keep falling asleep when I'm listening to the video. Not because he's boring, btw, I'm riveted. It's just another one of my symptoms.

    tee
  7. rebecca1995

    rebecca1995 Apple, anyone?

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    320 v. 218 controls

    Dr. Peterson talked about 320 controls at CFSAC, but the Science paper uses the figure 218.

    Any ideas about the cause of this discrepancy?

    Dr. P., from transcript:
  8. Dolphin

    Dolphin Senior Member

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    218 controls plus 101 patients is 319 in total. My guess is that is what Dr Peterson was referring to (he might have round 319 to 320 in his head or there might have been a problem with one of the samples).

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