I have been reading about theories that Dr Cheney and Dr Pall have around the nitric oxide cycle. They suggest a whole bunch of supplements that are said to help if taken in combination. I am doing methylation at the moment ( started 4 months ago) and so I am already taking methyl b12 ( 750mcg) and methyl folate (600mcg) I recently experimented with ecklonia cava; acai, pomegranate- as suggested in the dr pall protocol. BUT all of thee make me wose- I dont know if this is like a start up response , but would love to hear if anyone else has had any experience. I took 200mg ecklonia cava and felt really nauseas and chronic headpain- I have heard that the ecklonia cava can increase serotonin. Perhaps this is what was happening as my response was just like when I tried anti depressants. The acai and pomegranate I have taken seperately but both give me the same response even when I have lowered the dose ( I am now taking only 1/8teaspoon of pomegranate). the effects are bad nausea, headaches and worsening of itchy skin - and burning sensation to skin. the only other time I have had these reactions is to candida die off- perhaps that is causing the symptoms. Any thoughts or eperiences with these supplements or the Pall protocol?