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Dr Les Simpson...Able to Identify CFS by Blood Cell Shape

Discussion in 'General ME/CFS Discussion' started by gregh286, Jun 15, 2015.

  1. gregh286

    gregh286 Senior Member

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    Hi,
    I have read quite a lot of articles about this NZ doctor who was able to tell who had CFS and who didnt by looking at blood cell structure,
    This was 3 decades ago...just wondering was his work ever followed up after he retired.
    Modern Day CFS physicians certainly identify blood flood as major issue,
    Seems interesting that here was a guy 30 years ago who could detect CFS and yet it seemed to gain little traction?


    http://www.anapsid.org/cnd/diagnosis/redcells.html
    http://www.positivehealth.com/artic...-of-blood-flow-and-evening-primrose-oil-in-me
     
    rosie26 likes this.
  2. Esther12

    Esther12 Senior Member

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    If it held up under double-blind conditions it would have been amazing and got a lot of attention. My guess is that it didn't.
     
  3. gregh286

    gregh286 Senior Member

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    Prehaps a double blind was never conducted on it.
    may have slipped under.the net.
     
  4. Esther12

    Esther12 Senior Member

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    Maybe. I don't know anything about this stuff, but it doesn't sound right to me. My guess is that it's BS.
     
  5. gregh286

    gregh286 Senior Member

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    MadeleineKM likes this.
  6. Kina

    Kina Admin Support Staff

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    http://cfidsreport.com/Articles/researchers/lessimpson.htm

    Prohealth has an article -- http://www.prohealth.com/library/showarticle.cfm?libid=19045 -- with a case study N=1 -- that supports Simpson's work.

    From -- http://www.erythos.com/gibsonenquiry/Docs/BRAME.doc -- Summary of Research Evidence on ME\CFS & Oral Presentations -- Compiled by BRAME for Parliamentary Research Inquiry on ME/CFS.
    December 2005 & April 2006
     
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  7. adreno

    adreno PR activist

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    If blood viscosity is a problem in ME, then piracetam or pentoxifylline should work well.
     
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  8. justy

    justy Senior Member

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    can this explain PEM or the fluctuating nature?
     
  9. leela

    leela Slow But Hopeful

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    This makes perfect sense to me, since from the beginning MCV always shows macrocytic anemia (b12-deficient enlargement/misshaping of the RBCs). However B12 injections never changed this, possibly due to not taking folate with it.
     
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  10. gregh286

    gregh286 Senior Member

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    helps explain why nitrates are successful with many.
    in my case and many other certainly alcohol does the trick too. (vasodilation and temporary blood thining)

    mishaped RBC combined with viscosity issues....is it a recipe for disaster.?
    RBC traffic jams :)
    Certainly can explain fluctuations as RBC are produced in high volumes continuosly......dynamic nature of human body means always fluctuation in blood flow......akin to fluctuations in Blood pressure, heart rate, body temp. etc.
    Tingling, numbness and coldness in extremities related to circulation.
    Also, many report "weak pulse" in crash....low cardiac output.
     
  11. out2lunch

    out2lunch Senior Member

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    For me, none of the OTC blood thinners worked. The only thing that's worked in me is heparin, which I inject daily in low doses.

    Because heparin is a biofilm buster, I'm not sure thinned blood is the only mechanism in play here. Other researchers have focused on biofilm in the capillary bed, generated by antigens hiding underneath. Perhaps this is the cause of misshapen blood cells that Dr Simpson identified? Antigens in bone marrow, altering the very nature of the RBC? And producing biofilm in the capillary bed which functionally narrows it?

    I think he was onto something significant here. But unless the causative factor can be identified, I don't know how important this finding will remain. Treating the symptoms isn't enough anymore. We need to find the cause and treat it.
     
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  12. ukxmrv

    ukxmrv Senior Member

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    I met Dr Simpson when he came to talk to a local ME group in London. He's a lovely man. Think one of the other support group leaders still corresponds with him. He's probably retired now.
    Dr Simpson worked with Prof Murdoch and others on the Tapanui Flu outbreak inNew Zealand.
    They could only get a pittance in funding to investigate these patients. The local health authority was dead against it.
     
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  13. gregh286

    gregh286 Senior Member

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    For sure an underlying pathogen is primary trigger for the RBC mishape, but I would be happy to treat symptoms for now until the medical brains can identify root trigger.
    Thats exactly what I am trying to do now is beat down the pathogen with abx and cowden protocol....supported with RBC supporting supplements....B12/Folate/P5P/Niacin/Echinea for production and Evening P.Oil/Omega 3 for RBC shape regulation as outlined by dr.simpson.
    For sure we need to find cause and treat it....but at this minute in time....nobody really knows what causes the PEM/VO2 Max/awful aerobic capacity.....this goes someway to explain the mechanism behind the energy drought.
     
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  14. Richard7

    Richard7 Senior Member

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    After couple of months back I read some of the info on Les Simpson and started taking EPO and cod liver oil. I thought it might apply to me because my peripheral O2% as measured by a blood oximeter was very low 88-94 on the day in question and was very different from finger to finger. Today the O2% is still low, 93-95, but it is not as low and the variability has gone down.

    I also have issues with POTS, and am a person not a testube so other things could be going on
     
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  15. alex3619

    alex3619 Senior Member

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    This is a really old debate. I participated in the early debates on this topic. Long, long ago now.Like many avenues of research it seems it has not gone very far.

    I would also advise being very cautious with EPO as it can also trigger relapse or severe side effects.
     
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  16. Richard7

    Richard7 Senior Member

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    Thanks Alex, I might take a rest from it and see if it changes anything.
     
  17. Richard7

    Richard7 Senior Member

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    I should add, my energy has been down for the last 6 weeks or so. I had put it down to some sort of virus, as this change has been accompanied by an increase in loose stools but they are right there on the EPO side effect list.
     
  18. gregh286

    gregh286 Senior Member

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    hi richard.
    fruitflow and/or reservatrol might be a useful alternative, and should come with less side effect.
    otherwise hot baths,,,,FIR suana and red wine.(not all same time :))
     
  19. adreno

    adreno PR activist

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    Evening primrose oil (EPO) should not be confused with erythropoietin, also known as EPO.
     
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  20. beaker

    beaker ME/cfs 1986

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    I know Bell and cheney were very interested in this back in the day and may of even had some patients evaluated and irregularities were found in their patients. gee it's so long ago.
    Too bad it never went anywhere, but they liked it and accepted this study back in the day.
     
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