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Doxycycline Hydrochloride or Hyclate

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by minkeygirl, Nov 18, 2015.

  1. minkeygirl

    minkeygirl But I Look So Good.

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    Can someone tell me the difference between the two? I can't seem to find anything on Dr. Google.

    Please tag me
     
  2. Valentijn

    Valentijn The Diabolic Logic

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    It sounds like "hyclate" is just an official contraction used for "monohydrochloride hemiethanolate hemihydrate".

    So I think they both mean exactly the same thing.
     
  3. minkeygirl

    minkeygirl But I Look So Good.

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    That's what I thought after I looked. But there is one that has a longer half life. Oh well

    Thanks @Valentijn
     
  4. Hip

    Hip Senior Member

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    This comment explains it nicely:
    So basically, both doxycycline hydrochloride and doxycycline hyclate are pretty much the same — both are doxycycline linked on to the HCl molecule; but in the case of the latter, water and ethanol get bound up into the solid crystal as well.

    (In the case of water getting bound up into crystals, this known as water of crystallization — but I did not know that ethanol can also become incorporated into the crystalline structure. And as the guy said, this is not just a wet crystal; the crystal substance will be completely dry, but water molecules get "imprisoned" inside the crystalline lattice).



    Doxycycline also seems to come in other forms: doxycycline monohydrate, doxycycline carrageenate, doxycycline calcium and doxycycline phosphate. Those are chemically different from doxycycline hydrochloride Ref: 1
     
    Last edited: Nov 19, 2015
    Valentijn likes this.

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