I have been taking probiotics for over a decade...they used to have an effect, but now they don't seem to do anything but cause bloating or have no effect at all. I tried taking probiotics while on doxy but I got very sick (flu-like) each time so I stopped. I figured the AB was killing off the probiotics immediately and the die-off was making me sick. Now I'm pursuing home made yogurt (from almond milk--I can't eat dairy or soy) and home made sauerkraut. And also taking new probiotics that I've never taken before like soil based ones (Prescript Assist) and this other probiotic mixture I found at a health food store that has lots of strains I've never heard of. I have thought about a fecal transplant, but the sad thing is I don't know anyone who is healthy or who I'd feel comfortable having as the fecal donor. Plus I read that it only brings minimal improvements if any at all. I've been considering making my own home made probiotic enema, but I'm not there yet. Oh, man. Good luck to us all.