I have several gene mutations and it appears my methylation is compromised is several different areas; glutathione, detox, neurotransmitters, gut, others. I'm wondering if dopamine might be one of the bigger and more significant issues relating to my symptoms. I did an organic acid test and my HOMOVANILLATE result was 10 on a range of 8-50 so 5%, which appears to mean my dopamine is very very low. I have all the symptoms of low or deficient dopamine and I have them to the extreme. Is the solution to take L-dopa which is the direct precursor to dopamine, or L-tyrosine which is the precursor to dopa? And how long should it take to get a response? I read that you should feel it fairly quickly. And I assume if not, then this dopamine deficiency is not likely the primary cause of my symptoms, although it could still be part of the bigger picture. Anyone else had any experience with this?