I am new to all of this but learning as much as I can. I have been fatigued and have had mood disorders for the last 10 years or so that has been progressively getting worse. It progressed into depression. My immediate concern is what is going on with my Dopamine. I researched depression and concluded that a lot of my issues appeared to deal with Dopamine. My doctor agreed and she put me on Welbutrin. It has helped a lot. I am no longer depressed and my mood has been entirely positive. I have been taking it 4 weeks now. I will be seeing a doctor in my area that has been mentioned on this forum a few times. I want to be educated when I see him. I am very confused with all of the mutations that contradict treatment of each other. Any insight or advice is appreciated. Here are my 23andme/Genetic Genie results. Homozygous: COMT V158M COMT H62H VDR Bsm Heterozygous: COMT P199P MTRR A66G MTRR A664A BHMT-02 BHMT-08 CBS C699T CBS A360A I had blood work done that revealed Folic Acid is normal >24.0 with a range of >5.0 NG/ML. Vitamin D, 25 OH is 17 range says optimal is 30-100 NG/ML. Doctor recommended 5000 iu's of D3 daily. However, I read 25 OH may show that I am not deficient and just converting D really well. I believe 1,25 now needs to be tested to confirm. Thanks.