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Dopamine concern

Discussion in 'Genetic Testing and SNPs' started by Shenanigans, Aug 31, 2015.

  1. Shenanigans

    Shenanigans

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    I am new to all of this but learning as much as I can. I have been fatigued and have had mood disorders for the last 10 years or so that has been progressively getting worse. It progressed into depression. My immediate concern is what is going on with my Dopamine. I researched depression and concluded that a lot of my issues appeared to deal with Dopamine. My doctor agreed and she put me on Welbutrin. It has helped a lot. I am no longer depressed and my mood has been entirely positive. I have been taking it 4 weeks now. I will be seeing a doctor in my area that has been mentioned on this forum a few times. I want to be educated when I see him. I am very confused with all of the mutations that contradict treatment of each other. Any insight or advice is appreciated. Here are my 23andme/Genetic Genie results.

    Homozygous:
    • COMT V158M
    • COMT H62H
    • VDR Bsm
    Heterozygous:
    • COMT P199P
    • MTRR A66G
    • MTRR A664A
    • BHMT-02
    • BHMT-08
    • CBS C699T
    • CBS A360A
    I had blood work done that revealed Folic Acid is normal >24.0 with a range of >5.0 NG/ML.
    Vitamin D, 25 OH is 17 range says optimal is 30-100 NG/ML. Doctor recommended 5000 iu's of D3 daily. However, I read 25 OH may show that I am not deficient and just converting D really well. I believe 1,25 now needs to be tested to confirm. Thanks.
     
  2. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    Before I go into this more, since there are a few ways to create depression, I need to ask, do you have addiction issues in your family.?
     
    victoriana likes this.
  3. Shenanigans

    Shenanigans

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    Not that I am aware of. My grandparents on my paternal side were alcoholics. I don't seem to have any issues. I used to smoke in High School but easily gave it up.
     
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  4. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    victoriana likes this.
  5. Shenanigans

    Shenanigans

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    I just received the promethease report.
     
    Last edited: Aug 31, 2015
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  6. ppodhajski

    ppodhajski

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    Can you look up these SNPs for me?

    MAOB
    rs2283729
    rs1799836
    DDC (This is both AAAD and 5HTD in the pathways below, helping create serotonin and dopamine as well.)
    rs3735273
    rs1451375
    rs921451
    rs2329340
    rs1451371
    DBH
    rs77905
    rs1108580
    rs2007153
    TPH2
    rs4570625
    rs17110690
    rs4565946
    rs10506645
    rs1487278
    rs11179002
    TYR
    rs1393350
    rs1847134
    rs1799989

    These are all in the dopamine pathway. Here is a chart I made:

    Amine Pathway.jpg
     
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  7. Shenanigans

    Shenanigans

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    MAOB
    rs2283729 GG
    rs1799836 AA
    DDC
    rs3735273 GG
    rs1451375 AC
    rs921451 CT
    rs2329340 CT
    rs1451371 TT
    DBH
    rs77905 CC
    rs1108580 GG
    rs2007153 AG
    TPH2
    rs4570625 GG
    rs17110690 AG
    rs4565946 CC
    rs10506645 CT
    rs1487278 CT
    rs11179002 CT
    TYR
    rs1393350 GG
    rs1847134 AA
    rs1799989 CC
     
    ppodhajski likes this.
  8. Critterina

    Critterina Senior Member

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    Arizona, USA
    @ppodhajski, that's a great chart - I've been wondering about those pathways. And that you have the cofactors, too, is wonderful.

    Not to nit pic, but the phenylaline - is that supposed to be phenylalanine? Maybe I'm remembering wrong.
     
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  9. ppodhajski

    ppodhajski

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    Ha, yes, thanks. That happens to a lot. I need a full time proof reader.

    And I need to add some cofactors on there as well. GCH1 uses Zinc, for example.
     
    Last edited: Aug 31, 2015
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  10. ppodhajski

    ppodhajski

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    This is my pathway with my slow enzymes marked. It makes it easier for me to visualize where things might get stuck.


    Amine Pathway Christian.jpg
     
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  11. ppodhajski

    ppodhajski

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    Have you ever tried taking P5P (a form of B6)?

    Few more genes to look up!
    GCH1
    rs4411417
    rs752688
    rs8007267
    PTS
    rs3819331

    Here is your pathway flow so far. I can theorize that a lack of B6 (P5P), or if you have a problem metabolizing it could cause dopamine issues.

    Amine Pathway sn.jpg
     
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  12. Shenanigans

    Shenanigans

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    Few more genes to look up!
    GCH1
    rs4411417 TT
    rs752688 CC
    rs8007267 CC
    PTS
    rs3819331 CC

    I am at the beginning of this journey so I have not tried anything. My concern is that if I start treating the underlying causes it could cause some ill effects with the Welbutrin (i.e. psychotic episode or something). I very much appreciate you taking the time to walk me through this.
     
  13. ppodhajski

    ppodhajski

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    That PTS rs3819331 CC is interesting and it uses ZInc as a cofactor. Looks like it could lead to BH4 deficiency which will leave you low in all the neurotransmitters.

    http://ghr.nlm.nih.gov/gene/PTS
    http://www.uniprot.org/uniprot/Q03393
    http://www.nature.com/jhg/journal/v57/n2/full/jhg2011146a.html

    There is scant research on this SNP but it seems associated with Autism:
    http://onlinelibrary.wiley.com/doi/10.1111/j.1601-183X.2009.00521.x/pdf

    There is a brand of zinc called Optizinc you might want to try.

    Here is your final map. If I had these SNPs I would start with the Zinc and B6, then add Magnesium.

    Amine Pathway sn.jpg
     
  14. Hip

    Hip Senior Member

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    Since you had no depression 10 years ago, its triggering cause cannot not really be an issue of your SNPs, which remain the same throughout life.

    What makes you conclude that dopamine is behind your depression, rather than serotonin? Have you ever tried anything (drug or supplement) that boosts the serotonergic system? High-dose inositol for example?

    I myself find that both serotonergic and dopaminergic interventions improve my depression.

    I hope the benefits of Wellbutrin continue for you, by the way. I had spectacularly good results from Wellbutrin (see this post), for both my ME/CFS brain fog, and for my depression / anhedonia.

    Sadly, after two weeks on Wellbutrin, this drug completely stopped working for me. If you look online, and search for the "Wellbutrin 2 week honeymoon", you will see that several people have reported that Wellbutrin worked very well for them initially, but then after a few weeks stopped working.
     
  15. ppodhajski

    ppodhajski

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    Yes, the genes stay the same but the enzyme activity of the gene can change from quite a few factors.

    Age
    http://www.genomebiology.com/2013/14/7/R75

    Cofactor and Coenzyme availability
    http://www.ncbi.nlm.nih.gov/pubmed/16214324
    http://www.ncbi.nlm.nih.gov/pubmed/10089110

    As well as temperature
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1594916/

    SNPs in genes will make us more sensitive to those external factors.

    I was on prozac, lamictal, seroquel, klonapin, wellbutrin, celexa, depakote, zyprexa....on and on. I no longer need any of them now and I have been sympton for one year thanks to Nutritional Genomics.
     
  16. Hip

    Hip Senior Member

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    That study is on bacteria, whose environment can vary considerably with temperature, but is inappropriate for humans, whose temperature is tightly regulated at 37ºC.



    You make it sound as if you tailored a specific nutritional regimen for yourself which addressed your particular SNPs; but if I remember rightly, the crux of your regimen was riboflavin-5′-phosphate (R5P), which is involved in many SNPs, and so is not really specific to your SNPs.

    The fact that R5P helped you is great; but I am not sure that you can say this was because you figured it all out from nutritional genomics.
     
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  17. Violeta

    Violeta Senior Member

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    Then what are heat shock proteins for?

    I can't remember the last time my temperature was 37'C.

    And fever certainly can take one's temp way above 37C.
     
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  18. Hip

    Hip Senior Member

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  19. Violeta

    Violeta Senior Member

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    What do you mean, @Hip ?
     
  20. ppodhajski

    ppodhajski

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    Enzymes work the same no mater what the organism. But if that is too much for you to get right now here is one that shows genes in a human cell line.

    Common gene expression patterns responsive to mild temperature hyperthermia in normal human fibroblastic cells.
    http://www.ncbi.nlm.nih.gov/pubmed/23311377

    I am wondering why you only picked that one to critique? Do that man you agree the age and Cofactor and Coenzyme availability?

    Your confusion and doubt is a sign that you do not understand Nutritional Genomics. If you are having an issue understanding this method I can explain it to you. You can say you are not sure of this method but it will not aid in your comprehension.

    You can ask @ahmo about his Nutrigenomic experience as well.

    You can read more about Nutritional Genomics here:
    http://www.nchpeg.org/nutrition/index.php?option=com_content&view=article&id=397
    http://nutrigenomics.ucdavis.edu/?page=information

    And I also posted another video in the forum that you might watch.
     
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