My wife had all the classic ME/CFS symptoms, depression, anxiety. Freddds' protocol improved her symptoms in 2 months to about 90% health. Initially, she could go 3-4 days without supplements before the CFS symptoms started to return. Currently (after 3 years of the protocol), she can go about 2-3 weeks without supplements before symptoms return. There are a lot of factors here like diet, stress, etc.... But, it has me thinking that it all has to do with the gut. The root cause has always bothered me. And from a healing standpoint, it really doesn't matter. The protocols seem to bypass the "root cause". She had anxiety, depression and a weak immune system all of her life, but her debilitating symptoms started with GI issues and the more I think about how this all works, I always come back to the gut. I think there are three probable candidates for a root cause. Detox Mechanisms (glutathione production, methylation, etc..) Immune System Digestive System (gut) It would seem that: A poor functioning gut could cause a weak immune system and vitamins would override that A poor functioning gut could cause a breakdown in your ability to detox and vitamins would override that. It would seem less likely that A poor functioning detox system would trigger poor digestion. A poor functioning immune system would trigger poor digestion. Antibiotics should kill the infections, and return digestion to normal, they don't. Indicators: Celiac patients have the same symptom set and this seems to be a straightforward causal relationship. Folic acid will crash the whole system in a few hours. Even when methylation is going (methylfolate, Adb12, Mb12, LCF), my wife still needs basic vitamins (A, C, Calium, Mag, Zinc) to keep her immune system going. People with a burdened immune system from infection dont run into digestion problems. Once infections are under control, the digestive system should go back to work in ME/CFS.