I've tried searching both online and on this forum to find the answer to my questions, and couldn't really find much of anything anywhere (unless I overlooked something). I'm hoping that some of the very smart people here can help me to understand how to use whey properly, because our first usage of it was a slight disaster. I just got a very high quality grass-fed non-denatured whey protein powder for my husband, who has CFS and posts here sometimes. After reading an article that described how Cheney used whey in his clinic (patients took 10-20mg on an empty stomach first thing in the morning and he even sometimes had them take an antacid beforehand to avoid stomach acid digesting the whey), we decided that he would follow the same protocol. (I should preface this by saying he has no milk/casein/lactose allergies whatsoever). He took 2 Tums on an empty stomach, then drank the whey protein mixed with water. Within about 1 hour, he got one of his famous IBS diarrhea attacks (which lately have not been happening frequently). He's thinking it happened because ultimately it's not a good thing to have any undigested protein hit the intestine, and that could be what triggered him (undigested meat is a huge IBS trigger for his mom, which was solved by taking HCl with her meals). So, we're planning to try it again tomorrow without the Tums and/or possibly with a meal to see if he reacts differently. My questions are: 1) Is it actually important to take non-denatured whey on an empty stomach? Is this how you folks who take whey are consuming it? 2) If protein is broken down into amino acids in the stomach via stomach acid, doesn't this mean that amino acids can handle exposure to an acidic environment without degrading? 3) And lastly, does the presence of stomach acid completely negate any benefit of taking this stuff?