Myself, and I understand a bunch of others around here, get considerable symptom remission from opiates/opioids. I've often wondered why, there are 2 obvious effects: analgesia, and euphoric mood lifting. Of course, those 2 themselves would explain some kind of improvement, but the benefits go far beyond that, including the staving off of PEM. Furthermore, the downside is that tolerance and dependance are always waiting in the wings. I've been wondering why I got 2 1/2 days remission from a cold/sinusitis this week, and have seen the popular Th1/Th2 imbalance theory. So in my studies, I wondered if opiates are affecting similar systems, an lo and behold I found this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916179/ So, does that contain some clue about the immune modulating effects of opiates that is possibly mirrored by actually catching a virus/fever? (Eg, some parts of immune system are enhanced, others are subdued). Also, of interest in particular, I would be so bold as to imagine that those who also experience remission during or before a viral infection would ALSO be those who report benefits from taking (decent doses of) opiates or opioids? Anyone else out there fit that mould?