How we can hijack the media, in four easy lessons
Love it, hate it, good story, bad story... the media are going to keep reporting on ME/CFS no matter what. But isn’t it time that we saw that coverage as an opportunity?
Discuss the article on the Forums.

Does pantothenic acid (B5) 'stimulate' the adrenals?

Discussion in 'Alternative Therapies' started by dannybex, Jan 2, 2014.

  1. dannybex

    dannybex Senior Member

    Messages:
    2,595
    Likes:
    966
    Seattle
    Weird question I know, but about 2 years ago I was told not to take pantothenic acid, because my adrenals were diagnosed as being in the 'burnout' stage -- i.e., putting out too much cortisol at certain times of the day -- and taking any B-5 would just make things worse.

    So I've avoided taking it, things haven't gotten any better, in fact are worse, and so now I'm wondering if it's perhaps something I should've been taking, even in small doses, all along.I've read that cortisol is made from pantothenic acid and cholesterol…not sure if that's correct…but I guess my question still comes back to…Does B-5 actually stimulate the adrenals to put out more cortisol?Thanks in advance,

    Dan
     
    allyb likes this.
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    8,064
    Likes:
    6,203
    australia (brisbane)
    I remember reading that the dose used was 1000mg and above.
    The first time i used 1000mg it overstimulated me alot and had issues sleeping.
    I did use lower dose 500mg and it did help with energy.
    Im not really sure by what mechanisms it works.
    I didnt follow on much with the b5 as i ended up using dhea and pregnenolone instead.
    I think i read it from dr lam's adrernal fatigue site where he recommended high doses of vit c and b5.
     
  3. dannybex

    dannybex Senior Member

    Messages:
    2,595
    Likes:
    966
    Seattle
    Thanks Heaps, that's kind of what I've read elsewhere. I did look on Lams site awhile back and while he gives lots of information, he also is kind of vague, and says he can only answer in specifics if one does a consultation or program with him. Which makes sense, but that's why I haven't been able to get answers there…yet. :)
     
  4. dannybex

    dannybex Senior Member

    Messages:
    2,595
    Likes:
    966
    Seattle
    Almost a year later, and I still haven't really taken the pantothenic plunge. Would be interested in hearing if anyone else felt like pantothenic acid was stimulating?
     
  5. Dreambirdie

    Dreambirdie work in progress

    Messages:
    5,273
    Likes:
    3,757
    N. California
    Hi Dan. I have been on and off with B5 (aka pantothenic acid) for years. I take it in conjunction with Vitamin C, usually taking twice as much B5 as Vit. C, in my case 500 mg B5/1000 mg Vit C up to 4 or 5 times a day.

    At times I have taken up to 3000 mg/day of B5 to help my tanked adreanls. I have never found it over-stimulating, (in fact there have been times where even high doses did not phase me), but I know other people who have.

    With supplements you never know how it will work for a specific individual.

    There are many other options to boost adrenals: schisandra, ashwghanda, eleuthero root, sarsparilla, and licorice. I rotate them around, so that I don't get too acclimated.
     
    dannybex and helen1 like this.
  6. dannybex

    dannybex Senior Member

    Messages:
    2,595
    Likes:
    966
    Seattle
    Thanks DB. Yup, we're all different, and of course that's a good thing, but when it comes to this #@**!!! illness, I wish we all had the same reactions. :)

    My BP has been fluctuating wildly the last couple years, (plus the old salicylate issue) so I don't think I could go with the herbals, esp licorice, but the other reason I was asking was because pantothenate is essential for so many other functions, and I'm starting to think that avoiding it has been a mistake.

    I've lost a lot of muscle, but also fat -- even though I never had much of either in the first place! But the fat pads on the bottom of my feet, and even on my fingertips have decreased significantly, and I remember reading something about PA's connection to fat metabolism and the krebs cycle.

    And then there's this:

    http://www.whfoods.com/genpage.php?tname=nutrient&dbid=87

    "In addition to breaking down fats as fuel, pantothenic acid—via the CoA molecule—is necessary for building fats for storage."

    http://www.whfoods.com/genpage.php?tname=nutrient&dbid=87

    I'm not exactly sure what they mean by when they say "for storage"…but definitely need to 'build fats'.
     
    Dreambirdie likes this.
  7. minkeygirl

    minkeygirl But I Look So Good.

    Messages:
    3,218
    Likes:
    2,465
    Left Coast
    @dannybex My NP wanted me to take 500 mgs pantothenic acid with Licorice solid extract for my adrenals. 500 mgs had me wired out of my mind so I stopped. When I went back to it I started really low, like 50 mgs and now have slowly worked up to 500 mgs no problem.

    My BP also fluctuates like crazy.

    I don't know if it's helping me, adrenal-wise but I'll stick with it.
     
    Hanna and dannybex like this.
  8. dannybex

    dannybex Senior Member

    Messages:
    2,595
    Likes:
    966
    Seattle
  9. minkeygirl

    minkeygirl But I Look So Good.

    Messages:
    3,218
    Likes:
    2,465
    Left Coast
    Oh and I take it in the mornings. I have pretty much no cortisol all day.

    I'm working with pregnenolone. I feel great but crash bad and higher doses of the sublingual which shoot my BP up really high. Also horrible anger and feeling like I was having a breakdown.

    There's a good thread here about pregnenolone if your interested.
     
    dannybex likes this.
  10. dannybex

    dannybex Senior Member

    Messages:
    2,595
    Likes:
    966
    Seattle
    I tried pregnenolone in 2013 -- and it helped in general, but stopped it later on as it I think it caused increased anxiety. There's a discussion about it over on HealClick as well.

    I'm going to completely stop any pantothenic acid -- I've just been taking the RDA in a very low dose multi-B, but have been doing much worse over the last month, so am stopping things I started during this period, and hopefully things will improve.

    I did find other mentions of pantothenic acid stimulating the adrenals, and also found this study, in rats, but still it showed stimulation:

    http://www.ncbi.nlm.nih.gov/pubmed/7776715
     
  11. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,065
    Likes:
    609
    I was interested in reading the study but the link points to a study on nicotinic acid. Do you still have the link to article you had in mind?

    Thx
     
  12. dannybex

    dannybex Senior Member

    Messages:
    2,595
    Likes:
    966
    Seattle
    Oy -- sorry @PeterPositive -- my brain is melting. Here's the correct link:

    http://www.ncbi.nlm.nih.gov/pubmed/18520055

    "These results clearly demonstrated that pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Additionally, these results also showed that pantothenic acid supplementation induced adrenal hyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH."
     
    PeterPositive likes this.
  13. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,065
    Likes:
    609
    Thanks!
    By the way, I found an old email from my doc where I was asking about B5 dosage for stress/cortisol support and he warned about not going too high because it could produce an effect opposite to the expected one. I am not sure though what would be such limit. At the time I was taking 200mg.

    cheers
     
    dannybex likes this.
  14. drob31

    drob31 Senior Member

    Messages:
    831
    Likes:
    414
    I don't ever remember having a good experience with B5, and I have high cortisol.
     
    dannybex likes this.

See more popular forum discussions.

Share This Page