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Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in [CFS]

Discussion in 'Latest ME/CFS Research' started by MikeJackmin, Nov 12, 2014.

  1. MikeJackmin

    MikeJackmin Senior Member

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    Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome?

    Antioxid Redox Signal. 2014 Nov 11. [Epub ahead of print]
    Castro-Marrero J1, Cordero MD, Segundo MJ, Saez-Francas N, Calvo N, Román-Malo L, Aliste L, Fernandez de Sevilla T, Alegre-Martin J.

    NIH link here:

    http://www.ncbi.nlm.nih.gov/pubmed/25386668

    Summary here:

    http://www.bioportfolio.com/resourc...prove-fatigue-and-biochemical-parameters.html

    "Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. We conducted an 8-weeks randomized, double-blind, placebo-controlled trial to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients. This study was registered in ClinicalTrials.gov (NCT02063126). A significant improvement of fatigue showing a reduction in FIS total score (p< 0.05) was reported in treated group vs. placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p< 0.001), CoQ10 (p< 0.05), ATP (p< 0.05) and citrate synthase (p< 0.05) were significantly higher and lipoperoxides (p< 0.05) were significantly lower in blood mononuclear cells (BMCs) of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confers potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings."
    More details here:

    http://clinicaltrials.gov/show/NCT02063126

    They tested substance was "oral ReConnect supplementation ( NADH: 20 mg/day, Coenzyme Q10: 200 mg/day; 4 tablets/day)".
     
    Last edited: Nov 12, 2014
    Roseblossom, Mij, jimells and 3 others like this.
  2. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    This is not a surprise. Many of us find combining these two very helpful,. What we do not know is which patients improve. It would be good to see what the responder versus non responder rates are. Also the effect size is important, and whether or not objective function measures were used.
     
    jeff_w likes this.
  3. Hip

    Hip Senior Member

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    cigana and Simon like this.
  4. Simon

    Simon

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    Monmouth, UK
    Interesting results given a reasonable sample size of 73 and a double-blind placebo control.

    @Hip, those studies are from 1999:

    Therapeutic effects of oral NADH on the symptoms of patients with c... - PubMed - NCBI

    I'm assuming there was no report on that open label study, which makes me suspect it didn't work, assuming it went ahead. I do remember these supplements were both much vaunted in the late 1990s so was slightly surprised to see a new study on it now.
     
  5. Hip

    Hip Senior Member

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    I regularly used Q10 and NADH both before I developed ME/CFS 10 years ago, and afterwards too. They tended to have more powerful effects on me before I developed ME/CFS, but they still work to reasonable degree with my ME/CFS. Both supplements seem to perk up my mood and increase energy for me, particularly NADH. Doses I use are typically Q10 300 mg, and NADH 10 mg. NADH must be taken sublingually.

    The effects of a single dose of NADH I find last a whole day, whereas Q10 wears off after half a day or so. It's best not to take NADH in the evening, as the zing it creates in your mind can keep you awake. Though it's fine if you take NADH in the morning, because it then wears off by bedtime.
     
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  6. Dolphin

    Dolphin Senior Member

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    Full text now available free here: http://www.tritolonen.fi/files/pdf/ARS-2014-6181-Castro-Marrero_1P.pdf
     
  7. Dolphin

    Dolphin Senior Member

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    The size of the improvement on the FIS is not large

    Castro-Marrero Table 2.png
     
    Valentijn likes this.

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