Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? Antioxid Redox Signal. 2014 Nov 11. [Epub ahead of print] Castro-Marrero J1, Cordero MD, Segundo MJ, Saez-Francas N, Calvo N, Román-Malo L, Aliste L, Fernandez de Sevilla T, Alegre-Martin J. NIH link here: http://www.ncbi.nlm.nih.gov/pubmed/25386668 Summary here: http://www.bioportfolio.com/resourc...prove-fatigue-and-biochemical-parameters.html "Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. We conducted an 8-weeks randomized, double-blind, placebo-controlled trial to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients. This study was registered in ClinicalTrials.gov (NCT02063126). A significant improvement of fatigue showing a reduction in FIS total score (p< 0.05) was reported in treated group vs. placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p< 0.001), CoQ10 (p< 0.05), ATP (p< 0.05) and citrate synthase (p< 0.05) were significantly higher and lipoperoxides (p< 0.05) were significantly lower in blood mononuclear cells (BMCs) of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confers potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings." More details here: http://clinicaltrials.gov/show/NCT02063126 They tested substance was "oral ReConnect supplementation ( NADH: 20 mg/day, Coenzyme Q10: 200 mg/day; 4 tablets/day)".