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Does new Hep C drug sofosbuvir have any antiviral activity against coxsackievirus?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by RYO, Nov 11, 2013.

  1. RYO

    RYO

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    Dr Chia has suggested that a new Hep C drug (polymerase inhibitor) may treat chronic enteroviral infections. Does anyone know if any virologist/researcher has put this theory to the test? Can anyone site a basis for why sofosbuvir should work on Coxsackievirus?
  2. vli

    vli

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    hi @RYO --has he prescribed it to you?
  3. RYO

    RYO

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    No, medication does not come out until 12/8/13. I spoke with a pharmacist who works for Gilead. Their staff members have not tested sofosfuvir on coxsackievirus.
  4. vli

    vli

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    Well that date is pretty soon. Will you get it? Personally I trust Chia because I think there's substantial evidence for an enteroviral connection and frankly no drugs have been given for it so far, and if Chia thinks this drug may work on the enteroviruses, then I'm all for it. I'm open to be corrected by members far more knowelegable than me about this though.
  5. alex3619

    alex3619 Senior Member

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    Interesting.
  6. vli

    vli

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    hi @alex3619 --not trying to "suck up" to you or anything (!!!!) but you seem to be quite knowledgable abt these sorts of things, what's your opinion of this drug/ and dr Chia's recommendation of it? do you think Chia has something there?
  7. alex3619

    alex3619 Senior Member

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    Sofosbuvir does not kill viruses. It slows viral replication if it chemically matches the polymerase used to make new virus. So it slows the spread, and gives the body more time to fight it, but does not itself kill the virus. That is still up to the immune system.

    http://en.wikipedia.org/wiki/Sofosbuvir
    Ema, Firestormm and Valentijn like this.
  8. RYO

    RYO

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    It sounds like Gilead's other Hep C drug Ledipasvir (NS5A protein inhibitor) which was studied in combination with sofosbuvir may also be promising for treating enteroviral infections. Any thoughts or comments are greatly appreciated. I suffer from fatigue and significant hip girdle weakness after severe viral illness in May, 2012.

    http://www.sciencedirect.com/science/article/pii/S0042682205005283
    Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein
  9. Hip

    Hip Senior Member

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    @RYO
    Thanks for posting this.

    In this article a few years ago Dr John Chia said a hepatitis C drug in development should inhibit enteroviral RNA. However, this article did not mention which hepatitis C drug Chia was referring to.

    How did you find out it was sofosbuvir that Chia was referring to?
    Last edited: Nov 13, 2013
  10. RYO

    RYO

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    I am an internal medicine physician. Dr. Chia helped confirm my diagnosis when I initially became ill. I have contacted him over the last 2 years. I have tremendous respect for the work that he is doing. However, these antivirals are new and Gilead has not tested them against coxsackievirus. A Gilead pharmacist said they would consider a trial but we probably need a virologist, clinical researcher, and a well designed study.
    ukxmrv likes this.
  11. Hip

    Hip Senior Member

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    @RYO
    Isn't Dr Chia going to be pursuing the use of sofosbuvir for enterovirus-assoctiated ME/CFS as soon as this drug becomes available?

    Gilead should be enthusiastic for a trial of sofosbuvir for coxsackievirus B, I would have thought. I read that sofosbuvir will be quite expensive because of its high cure rate for hep C. The high cure rate means the drug is only taken for a short time, and then stopped, which apparently precludes mass production economies of scale. However, in the case of coxsackievirus B, I imagine it will probably only inhibit, not cure this virus, so ME/CFS patients would probably need to take this drug long term, which should increase sofosbuvir sales.


    Chia's work is extraordinary. If only other researchers would set about replicating his results, particularly his findings of enterovirus VP1 protein and enterovirus RNA in the stomach tissue biopsies of most of his ME/CFS patients.
    Last edited: Nov 14, 2013
    merylg likes this.
  12. acer2000

    acer2000 Senior Member

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    Its interesting. If you Google "sofosbuvir" you get some links to clinical trials on the clinicaltrials.gov website for its use in Hepatitis. But some of them have a "keyword" of "enterovirus infections" under the section additional MeSH terms. No mention of enterovirus in the body text of the description for the clinical trial though.

    For example:

    http://clinicaltrials.gov/show/NCT01851330

    Could be a sign?
  13. Hip

    Hip Senior Member

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    It says here that sofosbuvir is an RNA polymerase inhibitor, so this may be the mechanism by which sofosbuvir could inhibit enteroviruses / picornaviruses.

    A while ago I tried taking the drug amiloride, which has been shown to strongly inhibit coxsackievirus B3 replication. This antiviral mechanism of amiloride is through the inhibition coxsackievirus RNA polymerase.

    At the doses of amiloride I was taking, up to 15 mg daily, I did not notice much in the way of symptomatic improvements in my ME/CFS, but my tests were only short term (I only took amiloride for a few weeks).

    I ought to try amiloride again, taking 5 mg x 3 daily for say three months.


    By the way, another patient of Dr John Chia that I conversed with said the hepatitis C drug Dr Chia though might help ME/CFS patients was in fact one from Abbott. If I understood it correctly, I believe this new Abbott hepatitis C drug comprises three compounds: ABT-450, ABT-333 and ABT-267 (see: Abbott Hepatitis C Regimen).

    ABT-450 is a a protease inhibitor
    ABT-333 is a polymerase inhibitor
    ABT-267 is a NS5A inhibitor

    Ref: here
    Last edited: Nov 15, 2013
  14. Hip

    Hip Senior Member

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    This is interesting:
    The entry of antiviral and antiretroviral drugs into the central nervous system

    The above study states that antiviral nucleosides and oligonucleotides appear to have limited entry into the brain when given systemically, which may hinder therapy of viral brain diseases, while some of the protease inhibitors may enter the brain more readily.

    If ME/CFS is driven by a coxsackievirus B or echovirus infection of the central nervous system (and studies such as this one indicate that brain infection with coxsackievirus B does occur), then you would need antiviral compounds that can cross the blood-brain barrier and penetrate the CNS.
  15. RYO

    RYO

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    A researcher in Belgium will soon be testing Gilead Hep C drugs against enterovirus in vitro. I will post results as they become available.
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  16. acer2000

    acer2000 Senior Member

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  17. RYO

    RYO

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    I just received email from Dr. De Palma from Belgium. New Hep C drugs from Gilead do not have any antiviral activity against enteroviruses.
  18. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    @RYO have u tried interferon or chia's oxymatrine??
  19. RYO

    RYO

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    Yes, I took equilibrant for 6-8 months. It helped with fatigue symptoms but did not improve my hip girdle strength. That is when I took Betaseron for 6 months based upon data from Dr. Kuhl who studied betaseron in viral cardiomyopathy patients. Unfortunately, my hip girdle strength only improved approximately 50%.
  20. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Interesting, thanks for replying.
    I just read how immunoglobulin is sometimes used for cardiomyopathy induced by enterovirus?? but from what i read it isnt a common treatment.
    Does dr chia prescribe interferon inducers like immunovir?

    cheers!!

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