I'm struggling to find an effective painkiller for inflammatory pain in my spine and back that is part of my ME. I tried co-codamol, but felt so doped up I couldn't take care of myself. So my doctor switched me to Naproxen (250mg, three a day). I've been on it for a week now and I'm still experiencing more fatigue and daytime sleepiness than usual and am again struggling to cope with the basics of daily living. I'm sleeping about three hours extra during the day. Fatigue or drowsiness isn't listed as one of the side effects of Naproxen. Although I've had this pain for years, it started to flare up two or three months ago and became debilitating, hence my search for a painkiller. I'm not sure whether the dopiness and extra fatigue are part of a general ME flare-up (just as the pain is) or a side-effect of the Naproxen. Because those symptoms aren't listed as Naproxen side-effects, I'm wondering if they are nevertheless side-effects for me and that I'm getting them because Naproxen acts differently on people with ME. Naproxen is an NSAID. Any views/experience?