I've been taking 1800mg per day of NAC for about two years now. Inflammation and pain didn't get any worse after starting it. Pain stays under control with hydroxoB12 unless I over-use a muscle. Inflammation had started before I begun taking NAC as well, and did not get any worse. CPR has tested high, but that was only tested once, and quite recently. MCS and food sensitivities also started well before taking NAC - since these are common ME/CFS symptoms, it seems likely that they are simply part of the disease, unless we are to believe that almost all ME/CFS patients are using the same supplements? I have never had angular chelitis. IBS also seems unlikely - I get constipation, but that is probably due to upregulation of the ADRA2A gene after exertion, since taking an ADRA2A antagonist rectifies the problem completely. I have no acne type lesions or infected follicles. I don't have oral lesions. I also don't have numbness of any sort. So how is it that I'm taking so much NAC without any of the supposedly unavoidable side effects? And how is that AIDS patients in numerous studies using large doses of NAC for long periods of time never had those side effects? Those trials were not performed by drug companies, as there's little money to be made in peddling a supplement, hence it would seem that they can be trusted to accurately report adverse effects.