I want to take niacin to help improve energy (in the Electron Transport Chain) in the mitochondria. However, I believe that niacin absorbs methyl groups. I understand some of the basic about methylation but not the details. I have a problem with lack of energy and find supplements like methylfolate and B12 are very helpful. These supplements could be doing other useful things than provide methyl groups but I have the general impression that more methyl is better for me. Would a daily dose of 250 or 500mg niacin counteract many of the benefit of other supplements which might be providing useful methyl groups?