Thanks @pattismith - actually I already take all of that, except for the B2, which I react to badly. And I take liquid methylB12 orally instead of hydroxocobalamin. I did injections several years ago, for a couple of years, but they made no difference. I seem to do best with the liquid. I also take d-ribose and folate. I was just hoping maybe there would be some magic thing I hadn't tried yet! These supplements do help though, I was worse off without them.