The 12th Invest in ME Research Conference June, 2017, Part 2
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Does Butyrate make you sick at first?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by ebethc, Sep 29, 2014.

  1. ebethc

    ebethc Senior Member

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    I just started taking butyrate a few days ago and I feel like I'm coming down with something... Achey, tired, any exertion makes me sweat...It's not a really melodramatic reaction, and I can tolerate it, but I do want to understand if it's typical and if it's going to go away soon. Is this an ammonia detox reaction? I just take a few each day.

    thanks
     
  2. Soundthealarm21

    Soundthealarm21 Senior Member

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    Dallas, TX
    I haven't taken butyrate in about a year, but it was absolutely awful for me. I was so freaking sick when taking it and it never seemed to want to end with me so I just stopped taking it.

    How long have you been on it?
     
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  3. *GG*

    *GG* Senior Member

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    Concord, NH
    What is butyrate taken for?

    GG
     
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  4. Sushi

    Sushi Senior Member Albuquerque

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    I think it is one of those things that varies from person to person. It was fine for me.

    Sushi
     
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  5. ebethc

    ebethc Senior Member

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    @Soundthealarm21 - it has only been a few days, so not long, but long enough that I'm wondering if this is me getting sick or if butyrate doesn't agree w me. I think I'll give a a break today and then try it again..

    @ggingues - it supposedly absorbs ammonia in the gut. i don't know if I'm having a detox reaction, or just getting sick for some other reason (I do get sick often anyway)

    @Sushi - how long did you take it? do you think that it helped you detox ammonia faster?
     
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  6. Sushi

    Sushi Senior Member Albuquerque

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    I forget, many months. I didn't notice a thing from it, so eventually stopped taking it. I don't have an ammonia problem that I am aware of.

    Sushi
     
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  7. JalapenoLuv

    JalapenoLuv

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    unknown
    My guess is you're overdosing. If you have working intestinal bacteria they make all the butyrate you need so it's an unnecessary supplement. On the other hand, if you're taking antibiotics it is great when combined with vitamin k2.
     
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  8. Daffodil

    Daffodil Senior Member

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    Butyrate made me REALLY sick and i had to stop it, too
     
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  9. wiltedflower77

    wiltedflower77

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    I know this is really old post!!! But just on second day of butyrate capsule and have felt worse both days. Light headed fatigue worse, sore throat, was hoping someone might have an explanation but of course doesn't look like it as with most CFS reactions!!
     
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  10. pattismith

    pattismith Senior Member

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    I wonder if this paper would explain why some people doesn't tolerate very well Butyrate.:thumbdown:

    Butyrate may activate abortive lytic EBV infection in cells with latent EBV...


    Activation of Lytic Epstein-Barr Virus (EBV) Infection by Radiation and Sodium Butyrate in Vitro and in Vivo: A Potential Method for Treating EBV-positive Malignancies


    October 2000
    Abstract
    The consistent presence of the EBV genome in certain tumors offers the potential for novel EBV-directed therapies. Switching the latent form of EBV infection present in most EBV-positive tumor cells into the cytolytic form may be clinically useful because lytic EBV infection leads to host cell destruction, and very few normal cells contain the EBV genome. It would also be therapeutically advantageous to induce expression of EBVencoded lytic proteins that convert the nucleoside analogues ganciclovir (GCV) and 3′-azido-3′deoxythymidine (AZT) into their active, cytotoxic forms. In this report, we have explored two different approaches for activating the lytic form of EBV infection in tumors. We show that γ-irradiation at clinically relevant doses induces lytic EBV infection in lymphoblastoid cell lines in vitro as well as in EBV-positive B-cell tumors in SCID mice.
    In addition, sodium butyrate (given as a single i.p. dose) is effective for activating lytic viral infection in some EBV tumor types in SCID mice. We also examined whether low-doseγ -irradiation treatment of EBV-positive lymphoblastoid cells in vitro promotes GCV or AZT susceptibility. The combination of radiation with either GCV or AZT induced significantly more cell killing in vitro than either radiation or prodrug treatment alone. Most importantly, we found that the combination of γ-irradiation and GCV was much more effective in treating EBV-positive lymphoblastoid tumors in SCID mice than either agent alone. Thus, GCV or AZT treatment could potentially enhance the therapeutic efficacy of radiation therapy for EBV-positive lymphomas in patients.
     
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