Myerhoff's _Peyote Hunt_ is a great introduction to shamanic tradional use of external inputs to access the spiritual. Given how hard that is on the body it's not something I'd counsel with CFIDS/ME. Ayahuasca (sp?) is about the same, AFAIK, quite hard on the system. If you have fungal or mold issues, magic mushrooms would also be right out. If you could clone yourself multiple times, then you could try various substances (drugs, food, vitamins) or meditative, electrical, musical inputs and see if they restored the access to that spiritual sense in a controlled study where N would still = 1. My surmise, though, is that rather than battering through whatever the existing barrier is, the better path is to heal the body, and the spiritual capacity ought to be restored at the same time. Pick your descriptive explanation for this loss: viruses impinge on some portion of the brain or nervous system; vibrational or subtle body out of synch and thus out of phase with the spiritual vibes; or merely having such an energy deficit that one just can't muster more than basic survival; or my favorite answer: D) All of the Above. Purely academic, but I have read it asserted here that the POTS/OI is one of the last things to leave you once recovering or in remission. So it makes me wonder where on that sequence of healing the spiritual capacity might pop back into the picture. I can't recall, did you do the gene testing and have you tried the methylation approach?