Hi everyone, I am bit unsure on how to determine a wild-type (normal) and a risk-allele of a SNP. According to this resource (http://www.hgmd.cf.ac.uk/docs/mut_nom.html) it says, for e.g., 76A>C denotes that at nucleotide 76 a A is changed to a C) - so, what I have taken from this is that 'A' is the norm and 'C' is the mutation. However, according to my GeniticGenie report, it says I am homozygous (CC allele) for AHCY-01 but, according to this website: https://www.pharmgkb.org/variant/rs819147, it has C > T - meaning that the C is the norm and T is the mutation so, that made me a bit baffled. Shortly, I realised that the website also has a table for the frequency for both versions of the SNP: C and T, where C has a lower total frequency and T has a higher total frequency. I cannot remember where I read this but, apparently, the popular allele is considered the wild-type and the non-popular allele is considered the 'risk allele'. If this true, would this make sense as to why my GeneticGenie report says I am homozygous for the AHCY-01 SNP? The reason why I am so fussed about this is because I want to examine my other SNPs that are not covered by GeneticGenie. So, really, what I am asking is if I want to determine my wild-type and risk alleles, do I also need to take in the frequency of the alleles into consideration? @Valentijn I hope you do not mind me tagging you in this thread because I see that you are knowledgeable in SNPs I do apologise if this question (or a similar one) has already been covered in another of thread.