The week I came down with this thing (whatever it is), 20 year ago, I was so sick I quit smoking cold turkey that week. That says a lot about the severity with which this thing hit me, because I was a pack a day guy who sat up in bed in the morning and lit a cigarette, otherwise it took me a lot to get out of bed. I'm convinced I was self-medicating against dormant mental illness, because it kicked in hard with my ME. I had tried to quit unsuccessfully. But that week I got SO SICK with whatever this is I just couldn't even smoke. But over the years I keep reading about neuroprotective / anti inflammatory properties of nicotine, and its impact on gut-brain mechanisms/transit time, not to mentioned tobacco is an MAO inhibitor, I've always wondered what would have happened to my disease if I had kept smoking. I should also say, it's now one of my last resort options. I'm so fed up with this thing lately I've decided to start trying things, and TAKING CHANCES. If I'm at the end of my rope, and if nicotine gum has no effect, I'm going to start smoking and see what happens. I am very curious about who here smokes, and what their level of illness is at. I remember reading Jay Goldstein experimented with nicotine patches on CFS patients with some success.