Just wondering out loud here to see if anyone else has thought on this , or heard any researchers talk about this. As I am in a post exertional flare up right now it seems pertinent. What could be the mechanism, whereby a person can feel relatively well, go out and do a few seemingly minor activitys with friends, then almost exactly to the hour, 24hrs later come on with all the flu like symptoms and end up prostate in bed ? How could a virus do this? This delay in symptoms is soooooo striking when I'm in a slightly better phase. Does the virus somehow get 'stimulated' into action by activity (stress) and it takes 24 hours for the body to react by sending out a cytokine response to quell the virus? This is how I've come to think of it, but have no idea whether this could be correct. It then takes me 3 days to get back to my "normal". Essentially the time frame of every other virus. Please note I have not always had this 'pattern'. When bedridden for 2 years, there seemed no pattern at all. How do others, more knowledgeable in virology/immunolgy "see" xmrv as causing the peculiar symptoms of this illness.