I've recently switched from 2X weekly methyl B shots with regular needles, given by my husband or a nurse at the clinic, to daily self-administered sub-Q shots. I have needles used for allergy testing that are less painful than regular shots because the needles are so thin. With these sub-Q shots, you pinch the skin and give the shot through the fat. The 3 sites I was told to use are the upper thighs, the stomach, and the fat under the arms. I'm starting to run out of places to inject on my thighs. At some point I may have to use my stomach, but I've been told it's more painful there. I'm reluctant to inject the fat under my arm because I wouldn't be able to steady the site before injecting since I have only 2 hands. @Kina, I've read in the forums that you are a nurse. Does the stomach have more nerves than the upper thighs? These days I'm sporting pink blotches on my upper thighs because the serum is that color and is going in more superficially than regular shots. I live in TX, so wear shorts much of the year, but luckily, my shorts are long enough that the Easter-candy pink spots are covered.