I saw my CFS doctor for a follow-up appointment today, after initially seeing her 8 weeks ago. At the first appointment, she ran a stool test, checked me for MTHFR, suggested I have a fungal issue (probably Candida) and instructed me to start detoxing with coffee enemas and Tox-ease by Beyond Balance. I couldn't afford the Tox-Ease, so have primarily been focusing on the enemas over the past 8 weeks. I get rather significant die-off reactions and see a lot of alien material excreted on a daily basis, but have had no overall improvement in my condition, aside from feeling acutely better for the remainder of the evening after doing the enema. My doctor is good, but a bit all-over-the-place and she throws a lot of information at you. I tested positive for a Strep overgrowth in my gut, and have non-detectable levels of Lacto and Bifido. She also thinks I have Bartonella due to red dots that have appeared all over my upper arms, and is testing me for it to make sure. She wants me to: 1. Start taking Methyl-folate (200mcg) for my methylation defects. 2. Start taking Oil of Oregano to kill the Strep and Candida. 3. Start a specialized probiotic she sold me containing only Lacto and Bifido strains. 4. Start using a Zinc + P5P cream I have to get compounded. 5. Start taking the Bartonella formula from Beyond Balance (and I suppose I will have to get the Tox-ease as well). She said to do each step for one week, then introduce the next. Here are my concerns: 1. My adrenal fatigue is really bad, and it makes tolerating herxes and die-off extremely difficult. The coffee enemas have helped a little bit, but other means of addressing the issue (Hydrocortisone, Earthing, herbs etc.) just made me feel worse. 2. Isn't it bad to start Methylfolate without the other B-vitamins, esp. B12? I cannot tolerate B12 due to crashes and told her that. I said I was worried about Methyltrapping if I started the Folate on its own, but I don't think she knew what I was referring to. So I feel nervous about embarking on methylation in a half-assed way without everything else I need, and without knowing if I'm going to be able to tolerate B12. At the same time, I am nervous about starting something as heavy-duty as Oil of Oregano, since any die-off seems to waylay me. I thought about taking the probiotic first (since I have to order all the other supplements from iherb anyway), but even the die-off from the last probiotic I tried (Miyarisan) was pretty intense. Any advice? Am I right to feel hesitant about starting methylation with just the M-folate, or can it be done that way?