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Do My Genes Explain why Methyl. Doesn't Work??

Discussion in 'Genetic Testing and SNPs' started by JAH, Feb 26, 2014.

  1. JAH

    JAH Senior Member

    Messages:
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    San Jose
    Hi Everyone,

    I have tried Rich's simplified methylation treatment and Freddds protocol, and have noticed nothing. Not good or bad, just like taking a placebo. My doctor thinks that infections may be blocking it's effectiveness. I had my genes tested at 23 and me and wonder if results can explain why treatments have failed. (Haven't yet received my docs feedback). Hoping you can give your opinions, results from genetic genie:

    Here are your homozygous mutations as indicated in your SNP gene table above (not including MTHFR):

    • COMT V158M
    • COMT H62H
    • CBS C699T
    Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR):

    • VDR Bsm
    • VDR Taq
    • MAO-A R297R
    • MTRR A66G
    • MTRR H595Y
    • MTRR K350A
    • BHMT-02
    • BHMT-04
    • BHMT-08
    Detox:

    Gene & VariationrsIDAllelesResult
    CYP1A1*2C A4889Grs1048943TT-/-
    CYP1A1 m3 T3205Crs4986883TT-/-
    CYP1A1 C2453Ars1799814GG-/-
    CYP1A2 164A>Crs762551AA-/-
    CYP1B1 L432Vrs1056836CC-/-
    CYP1B1 N453Srs1800440TT-/-
    CYP1B1 R48Grs10012--no call
    CYP2A6*2 1799T>Ars1801272AA-/-
    CYP2A6*20rs28399444II-/-
    CYP2C9*2 C430Trs1799853CC-/-
    CYP2C9*3 A1075Crs1057910AA-/-
    CYP2C19*17rs12248560CT+/-
    CYP2D6 S486Trs1135840CG+/-
    CYP2D6 100C>Trs1065852GG-/-
    CYP2D6 2850C>Trs16947AG+/-
    CYP2E1*1B 9896C>Grs2070676CG+/-
    CYP2E1*1B 10023G>Ars55897648GG-/-
    CYP2E1*4 4768G>Ars6413419GG-/-
    CYP3A4*1Brs2740574TT-/-
    CYP3A4*2 S222Prs55785340AA-/-
    CYP3A4*3 M445Trs4986910AA-/-
    CYP3A4*16 T185Srs12721627GG-/-
    GSTP1 I105Vrs1695AA-/-
    GSTP1 A114Vrs1138272CC-/-
    SOD2 A16Vrs4880GG+/+
    NAT1 R187Qrs4986782GG-/-
    NAT1 R64Wrs1805158CC-/-
    NAT2 I114Trs1801280CT+/-
    NAT2 R197Qrs1799930GG-/-
    NAT2 G286Ers1799931GG-/-
    NAT2 R64Qrs1801279GG-/-
    NAT2 K268Rrs1208AG+/-


    GeneResult
    GSTT1Absent*


    Thanks for reading...JAH
  2. Helen

    Helen Senior Member

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    Hi JAH,

    Are you sure that you really have an impaired methylation? A high homocysteine? The Methylation Pathways Panel can give you information about what is going on. http://www.hdri-usa.com/tests/methylation/ .
    JAH likes this.
  3. JAH

    JAH Senior Member

    Messages:
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    San Jose
    Hi Helen,

    I'm not sure if I have impaired methylation, my doctor assumed so based on my symptoms. My homocysteine was normal. Glutathione also normal. Ammonia a little high, which could mean an impaired detox pathway.

    Thank you for the link to the tests.

    JAH
  4. Helen

    Helen Senior Member

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    Hi JAH,

    I don´t think that we always can trust the labtest for homocysteine - unfortunately. I had a normal homocysteine in blood, an impaired methylation (low folates and reduced glutathione a. o.) according to the panel and later I was diagnosed with Lyme. I will do another test to see if the methylation is working now that I have had Lyme treatment.

    This study showed that CFS patients had a normal homocysteine in blood, but all had elevated homocysteine in spinal fluid
    http://informahealthcare.com/doi/abs/10.3109/03009749709105320?journalCode=rhe.

    Did you try mecobalamin injections every second day for some weeks-a month? You might need high and frequent doses of MeCbl.

    Helen
    jepps and JAH like this.
  5. JAH

    JAH Senior Member

    Messages:
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    158
    San Jose
    @Helen I haven't tried the injections, but that is an option that my doctor has presented. Do you think my 23 and me results show a methylation block?

    Thanks for your feedback.

    J
  6. Helen

    Helen Senior Member

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    JAH, I can´t say from your genetics if you have a methylation block, but you are at risk with your MTRR mutations to have an extra need for methylcobalamin (no MTHFR mutation that affect your folate metabolism). I would try mecobalamin injections as I suggested in my earlier post, and the labtest/panel before if possible.
    JAH likes this.
  7. Redbeard

    Redbeard

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    2
    Canada
    Hi JAH,
    I have the same homozygous CBS mutation that you have and four COMT +/+ SNPs. What I can tell you, from my own experience, is that methylcobalamin and methylfolate make me very agitated.

    Like you, I also have elevated ammonia and all of my urea cycle amino acids are deficient.

    Red
    JAH likes this.

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