Do MEs cause CFS?

that was interesting, but a slight curved ball. It's not talking about the process of creating Methyl groups, but about their application to genes.
Richard van Konenynberg did produce a fair amount of work, but it was never 'peer reviewed and published'. I am busy for a couple of weeks, but happy to email the stuff when I can find it.

 

I don't recall you saying this before. Have you worked formally in the field, or just have relevant qualifications?

 

I understand that at least one person here is already doing it.

 

I've had IV saline for OI. Works fine as long as I'm not in my worst state (when none of my other medications work). Then none of my OI treatments help. This study says it may be because of altered plasma renin activity. Dr Bell says IV saline doesn't work for those who are the least and most affected by ME.

 

I'm one of the few sufferers with hypertension. I have just created a poll to get an idea of how common this actually is in ME.

 

Post #2 in this thread quotes:

 

Not sure if my blogpost here relates to what you are talking about, but if you look at the section 'Connections between leaky gut and autoimmunity' you will find a link to a paper about how leaky gut may lead to autoimmunity. Here is the link to the paper.

 

I had saline infusions are part of another drug treatment (with IVIG) and didn't notice any positive changes in my health so I have not re-visited that idea again.

 

Here's a recently published paper on Autoimmunity and the Gut : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036413/

 

I wonder what @Jonathan Edwards thinks of this article. The author seems a bit 'alternative' - not that I necessarily see that as a problem, but I am having trouble finding website info about him or his 'Wellness Center' in Florida.

 

Hmm, could it be interpreted that there is an initial strong response with much release of Interferon-gamma, but as the condition progresses, that immune response weakens?

 

Thanks Alex. This really makes sense to me. Now where do I go from here. How do I get tested and treated ?

 

Yes, I realised that this was what was bothering the back of my mind although I could not put my finger on it at first. A primary problem with the autonomic system would not seem to get the time scale of symptoms right, I guess.

 

It seems to be a list of all the fashionable and not very rigorous ideas about autoimmunity rolled into the usual rag bag - the sort of thing that scores of trainees will write to get themselves a publication without having any in depth knowledge of the problem. Nothing actually adds up to a proper mechanism. There are a lot of accurate individual facts there but the overall picture is very naive, I think. Handle turning I would say, and maybe advertising!

 

part2 links to part 1R, correct URL below
http://iaomt.media.fnf.nu/networks/iaomt/IAOMT_talks_Rich_Van_K._2011__Part_2.pdf

 

was a response to Tanya, anybody meant 'in her medical team'....

 

I've always taken that delay as a sign of some kind of immune activity or inflammation. The time between overexertion and reaction (PEM) is about the same for me as the time between overexertion (lifting something, doing too much garden work) and pain for my dad who has AS.

It differs too: The more I've overdone it, the longer it takes until the crash, and of course, the worse it gets. If I've done a little bit too much I get worse later during the day. If I've done way too much it can take four or five days, or more. During which I feel just fine (well, for having severe ME) or even better than usual. Then I crash, badly. It's tricky that way.

 

Qualification only, doing my first piece of research now. Still at a very analytical / preparatory stage looking into energy management and the interactions of cellular metabolism and the endocrine manifestations of ME. Essentially it's a very complex network analysis. Like pretty much all researchers don't discuss it too permit later publication.

 

Since we don't really understand the problem, then treatment tends to be hit or miss. Its my Lemon Rule again. KDM does however attempt to deal with this, but LPS from the gut is only one of a range of potential issues. Testing is theoretically easier, but I am unsure how common commercial LPS testing is.