I am currently taking 7,5 mg mirtazapine and 10mg baclofen for sleep. Last week I started SMP, so far almost no reaction, only worse headaches. I've been taking that low dose of mirtazapine for few years now and when I try to taper it down I suffer from severe insomnia and I am so exhausted already that I can't function after one sleepless night. Do medications interfere with Methylation protocol? It seems they do, and I am most probably slow detoxifier, but what other choice do I have? Is SMP pointless when I am taking those medications?