1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Part 2: Brain Cells Making us Sick? Messed up microglia could be driving symptoms
Simon McGrath looks at theories that microglia, the brain's immune cells, might be overactive and driving the symptoms of ME/CFS and fibromyalgia.
Discuss the article on the Forums.

Do I need to tweak the methylation protocol for my son?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by harpazo_hope, Jan 11, 2013.

  1. harpazo_hope

    harpazo_hope

    Messages:
    8
    Likes:
    1
    I have been reading all I can about the different methylation protocols out there, and I came across this site - http://mthfr.net/taking-folate-and-feeling-badly-methylation-requires-balance/2011/11/15/ - which says "IMPORTANT!! Increased methylation may cause – and does cause – neurological symptoms."

    My son once had b6 and b12 injections and suffered terrifying hallucinations shortly after. He was also on a new antibiotic, so I can't be sure what if anything external caused the hallucinations. I'm guessing the B12 was cyanocobalamin and that we have never supplemented the correct forms of anything, but I'm still concerned. I am especially hesitant because the same page says supplementing methylfolate and methylcobalamine will elevate methionine levels. My sons methionine levels are already elevated though I haven't a clue what this means.

    The same web page talks of low B6 levels which my son also has.

    My son is getting close to 17 years old and has been diagnosed with Lyme disease. He has a host of physical and neurological symptoms. None of the treatments/supplements we have tried so far have helped him much.

    Anyway, my question is should all this information change how I go about the Active B12 Protocol? How? His B12 levels were okay. Are the recommended supplements easy to break in half?

    Right now I'm thinking about supplementing B-6 and magnesium like the link above suggested and a B-complex. Then after a while adding the b9 and b12 slowly. My doctor suggests we see a geneticist.

    I will also paste his NutrEval test results and my rewriting of the commentary. I'm on my own here as my doctor is not educated about this topic and we recently lost our insurance.


    B-Vitamins
    Thiamin - borderline
    Pyridoxine - borderline
    Folic Acid - borderline

    Minerals
    Magnesium - borderline
    Zinc - Low 6.5 (reference range 7.8-13.1 mcg/g)

    Need for Methylation - borderline

    Carbohydrate Metabolism
    Pyruvic Acid - borderline high2 6 (with reference range 7-32)

    Creatine concentration - borderline high 17.8 (with reference range 3.1-19.5 mmol/L)

    Neurotransmitter Metabolites
    Quinolinic Acid - borderline high 7.9 (with reference range <=9.1)
    Kynurenic/Quinolinic Ratio- low 0.34 (with reference range >=0.44)

    Toxin Detoxification Markers
    a-hydroxyisobutyric acid from MTBE - high 6.8( with reference range <=6.7)

    Nutritionally Essential Amino Acids
    Lysine - Low 38( with reference range of 34-226)
    Methionine - High 90 (with reference range of 26-69)
    Pheynylalanine - High 62( with reference range 22-61)
    Tryptophan - borderline 86 (reference range 23-88)

    Nonessential Protein Amino Acids
    Cystine - High 114 (reference range 23-68)
    Glutamic Acid - High 18 (Reference range 3-15)
    Tyrosine - borderline 104 (reference range 28-113)

    Intermediary Metabolites
    Glycine/Serine Metabolites
    Ethanolamine - High 581 (reference range 156-422)
    Phosphoserine - high 69 (reference range 26-64)
    Sarcosine - High 42 (reference range <=41)

    Dietary Peptide Related Markers
    Anserine (dipeptide) - borderline low 7 (reference range 8-118)
    Carnosine (dipeptide) - low 3 (reference range 12-120)

    Omega 9's - borderline 13.4 (reference range 13.3-16.6)

    Saturated Fatty Acids
    Palmitic - borderline 18 (reference range 18-23 wt%)
    Stearic - high 19 (reference range 14-17 wt %)
    Tricosanoic - high 0.25 (reference range 0.12-0.18)

    Omege 6 Fatty Acids - borderline high 38.2 (reference range 30.5-39.7)
    gamma-Linolenic - High 0.20 (reference range 0.03-0.13 wt %)
    Arachidonic - High 21 (reference range 15-21)
    Eicosadienoic - borderline high 0.21 (reference range <=0.26)

    Delta - 6 Desaturase Activity
    Linoleic/DGLA -borderline upregulated 6.6 (reference range 6.0-12.3

    Omega 3 Index - Low 3.9 (reference range <=4.0)

    lead, antimony, and arsenic were all measurable but within the reference range.

    Also, his WBC is always a little high...



    --2-HIBA was elevated and is a

    metabolite of a gasoline additive. This was just

    one decimal

    point from not being above the reference range,

    and I am guessing it isn't a problem...


    --Kynurenic Acid/Quinolinic Acid ratio was low

    which is associated with inflammation and overall

    neurotoxicity. Healing Lyme by Stephen Buhner says this QA is elevated when the spirochetes infect the brain.


    --He has low levels of a dietary peptide called

    anserine.

    "There is no clinical significance for low

    anserine."


    --Another dietary peptide, carnosine, was

    measured to be lower than the reference range.

    This is

    typically low or absent for individuals who eat

    low protein diets... NOT the case in our house!


    --The amino acid cystine was elevated, but

    without corresponding elevations in other amino

    acids.

    This is consistent with cystinuria - a genetic

    disorder that causes kidney stones. One of the

    symptoms is week fingernails, and his fingernails

    have crumbled right in the middle many times. It

    is also is associated with inflammatory responses

    and reduced ability to detoxify if limited

    glutathione results.



    --Phenylalanine measured elevated...

    This is linked to iron deficiency, subnormal

    tissue oxygenation, anemia, pulmonary disorders,

    cardiovascular

    problems, magnesium deficiency, aluminum excess,

    b3 and b1 deficiency, mitochondrial damage,

    biopterin insufficiency, adrenocortical

    insufficiency, addisons disease and insulin

    insufficiency, genetic weakness AND MORE.

    Symptoms with mild

    moderate hyperphenylalaninuria include fatigue,

    headaches, brain fog or mental confusion, nausea

    or diarrhea. Artificial sweeteners need to be

    avoided. We already do that.


    --Ethanolamine was elevated. Magnesium deficiency

    is frequently observed to coincide with this, and

    could be caused by excess microbial production of

    ethanolamine in the intestines and rate-limited

    formation of phosphoethanolamine from

    ethanolamine. A stool sample is needed to tell

    the difference. Other markers for intestinal disbiosis didn't get flagged.


    --Phosphoserine is an intermediary metabolite of

    serine formation from phosphoglycerate

    (glycolysis). It was elevated but serine is not.

    Also, phosphoethanolamine is not elevated. This

    suggests a rate limitation specific to the

    phosphoglycerate-to-serine pathway.

    This could be elevated due to a magnesium

    deficiency {which he has} or b6 deficiency

    {which he has} or coenzyme dysfunction of

    pyridoxal 5-phosphate. This elevated

    phosphoserine can cause vitamin D dysfunction, or

    hormone/steroid imbalances.


    --Methionine -amino acid- was elevated. This

    implies rate-limited impaired metabolism of this

    essential amino acid. This could have

    far-reaching consequences and multiple

    symptomatology. Magnesium may help.


    --Glutamic acid is elevated and dicarboxylic

    hyperaminoaciduria is not present.

    The known conditions consistent with this are

    ingestion of MSG, ingestion of nutritional

    supplements containing large amounts of glutamic

    acid, gout or pregout, some imbalance or

    impairment in purine metabolism, metabolic or

    renal acidosis. We avoid MSG, and he isn't on any supplements with glutamic acid.


    --Sarcosine is elevated wich suggests three

    possibilities.

    1.recent dietary supplementation of

    dimethylglycine.

    2.Deficiencies of folic acid, THF, b2,

    roboflavin. The methyl group fragment removed from sarcosine is at the oxidative level of CHO and can form

    formaldehyde and slow down sarcosine's catabolism

    while making it somewhat toxic.

    3. Genetic weakness which is rare.

    Unpublished clinical observations associate some

    cases of acquired, mild sarcosinuria with past

    exposures to organic chemical solvent and

    petrochemicals. It's not known to be toxic,

    however, folic acid supplementation is suggested

    whenever sarcosine is elevated. He was low on

    folic acid.


    --Linoleic acid was within reference range but

    below the functional physiologic range. Found in

    virtually all vegetable oils. Linoleic acid

    stimulates normal cellular division and cellular

    repair. Inadequate LA may result in eczema-like

    skin eruptions, behavioral disturbances,

    increased thirst, growth retardation, and

    impaired wound healing.


    --Arachidonic acid was within the reference

    range, but above the functional physiologic

    range. AA is

    also the main precursor for pro-inflammatory

    eicosanoid synthesis. It may contribute to a

    feed-forward inflammatory cascade and increased

    immune system activation.


    --Pentadecanoic acid and/or Tricosanoic acid are

    above the reference range. May indicate an

    increased need for b12 and biotin,

    or may result from an exceptionally high water-soluble fiber diet.


    --His lead, antimony, and arsenic were measurable

    but not high. This is his second

    heavy metals test with the same metals

    elevated... but they didn't test for as many

    metals this time. He's had two rounds of DMSA since testing.


    --And last but not least, his zinc was very low.

    He was also low on Thiamin, B6, Folic acid,

    magnesium, and lysine and the papers suggest we

    supplement them and omega 3's.
  2. place

    place Be Strong!

    Messages:
    278
    Likes:
    53
    US
    I wish I could help you but you have to become your expert as i did for my active b program. Read everything on fredd,s stuff also, search the web for the heart fixer. He has a great diagram on the methylation cycle.
    I have made good progress but it has taken a lot of trial and error with symptoms. I post a question to the group like I can't focus..... And then I get suggestions on what supplement to try. It will take time but it is well worth it. I would start with the full protocol and tweak. If he has no reaction to any of it, it won't work for him.
    harpazo_hope likes this.

See more popular forum discussions.

Share This Page