I'm a 37 year old guy with low energy issues. I'm not sure if I have mild CFS/ME or something else? Short summary: I had chronic-stress-induced adrenal exhaustion, treated it, and recovered - but not fully. I have functional levels of energy but "run out of steam" in the evenings and weekends. I can hold down my office job, exercise, cook & clean and be a loner without much problem... adding friendships and romantic involvements to the mix can be somewhat draining & challenging. I respond great to vitamins... and to glutathione... but am overstimulated by L-carnitine, d-ribose, CoQ10, NADH. Long Story: For my whole life, I have been an anxious, overambitious, hard worker type personality. To relieve stress I did high adrenaline sports and partying (dancing to electronic music all night). I ran a stressful technology business : for 8 years I spent 12 - 15 hours a day online, stressing and trying to be "#1 in my field" at any cost. I used (not abused) a prescribed stimulant medication for "ADD". In September 2011, my lifestyle caught up with me and I crashed down with severe, debilitating adrenal fatigue, .... and had to close my business. For the past 2.5 years I have been recovering from a severe case of AFS (Adrenal Fatigue Syndrome). I followed Dr. Lam's protocol of C & B5 vitamins, glutathione, yoga, meditation, lower carb diet... and I have achieved huge improvements in energy, health and physical appearance. I have cured most of my symptoms (collagen loss, salt craving, constant "fibromyalgia" pain & tension in back / neck, insomnia, thyroid imbalance, poor digestion, cortisol disregulation) with supplements, yoga and diet. My two remaining symptoms are: sunlight sensitivity & PEM. 15 - 20 minutes in the intense tropical sun can mildly crash me. If I try to do too much yardwork or housework in a stretch then my muscles will ache... and I feel a general malaise. I don't even want to listen to music, watch TV or read... it all seems overstimulating, slightly painful... I prefer to just sit silently in a darkened room or stare at the wall. If I really overdo things, sleep will become difficult to impossible. I tend to wake up very early... 6 A.M. or earlier... and sleeping as late as 8 A.M. is almost impossible. Now I work 35 hours a week at an office job and do hot power yoga. I look and feel good much of the time. But I apparently have some sort of ATP production or recycling issue. I can nearly always make it through the workweek... but sometimes I need to "recover" on the weekends... sit at home and do very little or else I run up an energy debt. If I keep pushing for multiple weeks in a row, then I have a delayed fatigue that catches up with me and makes it difficult to get through the workday. I can't "go out" for activities on multiple / consecutive evenings like I used to. I can't see live music anymore (dancing after 10pm in a bar is a recipe for a crash). I can't do many of the outdoor activities that people of my age (30s) are into. I can do yoga but I have to go home and rest, can't meet up with friends and socialize after. I can only got to the beach for 15 minutes or so because the sun is too intense. My body seems to have low glutathione. The first time I drank liposomal GSH, it felt very refreshing and rejuvenating. I recently started taking NAC and it improved my energy, libido and OCD slightly... feels like "something that my body wants." I respond well to most B vitamins (haven't tried B12 yet), C, D, E, magnesium, licorice, ashwaghanda. When I was really dragging, I was prescribed OTC thyroid glandular by an Endocrinologist and it helped a lot. But not back to 100% However, I am extremely oversensitive to mitochondrial supplements. 500mg Acetyl-L-carnitine makes me nervous and irritable. 12 - 30mg CoQ10 feels awesome first and then irritable later on. 2.5mg NADH seems awesome at first, but I feel "tingling" or strange if I take it on consecutive days. SAM-e taken in the far past caused overstimulation, insomnia... but sometimes lifted spirits. Hit or miss. 750mg - 1500mg d-ribose works great, but the energy drops off fast. Too spikey. 5 grams is unbearably overstimulating. 600mg NAC is awesome, feels "good" - no unpleasant effects.. but it is not strong enough to fix my fatigue. ---- Yes, my body can get tension & possible inflamed with too much stress, eating gluten, etc. (But it's manageable with yoga). I don't have no *obvious* infections or immune problems. I tested negative for giardia and h. prylori. I don't have any obvious exposure to toxic chemicals or metals - but it could be possible. Just nothing I am aware of. So does this sound like CFS? Or something else? Any tips for treatment? Thanks so much for reading and responding... I don't know who else to turn to (not local doctors!) etc.