The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Do I have any lost twins out there? ;-)

Discussion in 'Genetic Testing and SNPs' started by Gondwanaland, Nov 20, 2014.

  1. Gondwanaland

    Gondwanaland Senior Member

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    Gondwanaland.jpg

    I am just too dizzy to look up the interpretations right now :nervous:
    Any tips and comments are welcome!

    Edit: 2.3% Neanderthal
     
    Last edited: Nov 21, 2014
  2. Gondwanaland

    Gondwanaland Senior Member

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  3. Critterina

    Critterina Senior Member

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    Sorry, not a twin.

    Looks like you really need methylfolate. And some, but not so much, the methylB12.

    Does methylfolate cause neuro symptoms? I have seen where someone here was recommended folinic acid and BH2 to level out their supply of folate because they seemed sensitive to taking methylfolate directly. And she had SNP sort of like you, if I remember correctly.
     
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  4. Gondwanaland

    Gondwanaland Senior Member

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    Many thanks for your input, Crit.
    When I tried it back in March I took too high a dose... I'm not sure what I run into. Lack of cofactors for sure.
    I got breathlessness, anxiety, panic attacks, low potassium, food intolerances, agitation, sleeplessness (several weeks w/o yawning), wired & tired, weight loss, you name it. I am getting prepared to restart at a low dose.
     
  5. Gondwanaland

    Gondwanaland Senior Member

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    Just got my Sterling's Report.

    I am posting the +/+ and +/- results here in the hope to get some tips about what to look at and address first, since due to a current situation in my life I really don't have the time right now to delve in it with the needed attention.

    I will be very thankful for inputs, even if to let me know if "it is all in my head"...

    DETOX
    CYP1A2 C164A rs762551 C CC +/+
    CYP1B1 L432V rs1056836 C CG +/-
    CYP1B1 R48G rs10012 C CG +/-
    CYP2C9*3 A1075C rs1057910 C AC +/-
    CYP2D6 S486T rs1135840 G CG +/-
    CYP2D6 T2850C rs16947 A AG +/-
    CYP2E1*1B G9896C rs2070676 G CG +/-
    CYP2E1*1B G9896C rs2070676 G CG +/-
    NAT2 A803G (K268R) rs1208 G AG +/-
    NAT2 T341C (I114T) rs1801280 C CT +/-
    SOD2 rs2758331 A AC +/-
    SOD2 A16V rs4880 G AG +/-
    PON1 Q192R rs662 C CT +/-

    IgE
    IL-13 C1112T rs1800925 T CT +/-
    CD14 rs2569191 C CC +/+
    SOCS-1 -820G>T rs33977706 A AC +/-
    FCER1A rs2251746 C CT +/-
    RAD50 rs2040704 G AG +/-
    RAD50 rs2240032 T CT +/-

    IgG
    FCGR2A rs1801274 A AG +/-
    GSTM3 V224I rs7483 T CT +/-

    IgA
    IRF5 rs4728142 A AG +/-
    IGF1R rs2229765 A AG +/-
    IFIH1 (HLA) rs1990760 C CT +/-
    HLA-DQA2 rs9275224 A AG +/-
    MTC03P1 rs9275596 C CT +/-
    HLA-DPB2 / COL11A2P rs1883414 A AG +/-

    CLOTTING FACTORS
    CETP rs1800775 C AC +/-
    CYP4V2 rs13146272 C AC +/-
    ITGB3 T196C rs5918 C CT +/-
    NR1I2 rs1523127 C AC +/-
    F5 (Factor V Leiden) rs6025 T CT +/-

    METHYLATION
    ACE Del16 rs4343 G GG +/+
    ADD1 G460W rs4961 T GT +/-
    AGT M235T/C4072T rs699 G AG +/-
    AHCY-01 rs819147 C CT +/-
    AHCY-19 rs819171 C CT +/-
    BHMT-02 rs567754 T CT +/-
    BHMT-08 rs651852 T CT +/-
    CBS A360A rs1801181 A AG +/-
    COMT rs6269 G AG +/-
    COMT H62H rs4633 T CT +/-
    COMT V158M rs4680 A AG +/-
    DAO rs3741775 C CC +/+
    FOLR2 rs651933 A AG +/-
    FOLR3 rs7925545 G AG +/-
    FUT2 rs492602 G AG +/-
    FUT2 rs601338 A AG +/-
    FUT2 rs602662 A AG +/-
    GAD1 rs3749034 A AG +/-
    GAD1 rs2241165 C CT +/-
    GAD1 rs2058725 C CT +/-
    GAD1 rs3791850 A AG +/-
    GAD1 rs12185692 A AC +/-
    GAD1 rs10432420 A AG +/-
    GAD1 rs3828275 T CT +/-
    GAMT rs17851582 A AG +/-
    GAMT rs55776826 T CT +/-
    GIF (TCN3) rs558660 A AG +/-
    MAO A R297R rs6323 T TT +/+
    MTHFD1 C105T rs1076991 C CT +/-
    MTHFD1L rs17349743 C CC +/+
    MTHFD1L rs6922269 A AG +/-
    MTHFD1L rs803422 A AG +/-
    MTHFR 03 P39P rs2066470 A AG +/-
    MTHFR A1298C rs1801131 G GG +/+
    MTHFR A1572G rs17367504 G GG +/+

    MTHFR G1793A (R594Q) rs2274976 T CT +/-
    MTHFR rs13306560 T CT +/-
    MTHFR rs1476413 T CT +/-
    MTHFR rs17037390 A AA +/+
    MTHFR rs4846048 G AG +/-
    MTHFR rs4846049 T TT +/+
    MTHFS rs6495446 C CC +/+

    MTR A2756G rs1805087 G AG +/-
    MTRR K350A rs162036 G AG +/-
    MTRR rs3776467 G AG +/-
    MTRR rs9332 A AG +/-
    NOS2 rs2274894 T GT +/-
    NOS2 rs2248814 A AG +/-
    NOS3 rs1800783 A AA +/+
    NOS3 rs1800779 G GG +/+
    PEMT rs4646406 A AA +/+

    SHMT2 rs34095989 A AG +/-
    TCN1 rs526934 G AG +/-
    TCN2 C766G rs1801198 G CG +/-
    VDR Bsm rs1544410 T CT +/-

    CELIAC DISEASE/GLUTEN INTOLERANCE
    HLA rs2858331 G AG +/-
    HLA DQA1 rs2187668 T CT +/-

    THYROID
    CTLA4 rs231775 G AG +/-
    FOXE1 rs1867277 A AG +/-
    FOXE1 rs10984009 A AG +/-

    MITOCHONDRIAL FUNCTION
    COX5A rs8042694 G GG +/+
    NDUFS7 rs2332496 A AG +/-
    NDUFS7 rs1142530 T TT +/+

    OTHER IMMUNE FACTORS
    ATG16L1 rs10210302 T CT +/-
    GSDMB rs7216389 T CT +/-
    STAT4 rs10181656 G CG +/-

    SULFONOTRANSFERASE
    SULT1A1 rs35728980 G GT +/-
    SULT1A1 rs1042157 A AG +/-
    SULT2A1 rs4149452 T CT +/-
     
    Last edited: Nov 23, 2014
  6. WoolPippi

    WoolPippi Senior Member

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    yup, we're related :hug:

    You already know about the MAO A sensitivity we share but I compared my results to the ones you posted here and .... eh... 7 out of 11 match, including the two red ones!
    What does this this list concern? I know post 1 is about Methylation. What is post 2 about, Detox?
     
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  7. WoolPippi

    WoolPippi Senior Member

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    I only share two of your red markers in this post.

    METHYLATION:
    MTHFS rs6495446 C CC +/+

    MITOCHONDRIAL FUNCTION:
    I have AA on COX5A rs8042694 G GG +/+
    I have AA on NDUFS7 rs2332496 A AG +/-
    I share your TT NDUFS7 rs1142530 T TT +/+

    On the IgE I have no result for CD14 rs2569191

    All other homozygous results I did not share.

    But Valentijn says it's common as dirt. Here.
     
    Last edited: Apr 3, 2015
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  8. Gondwanaland

    Gondwanaland Senior Member

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    Yes, Liver metabolism (aka detox)
    I don't care about how common they are... What I really want to know is in what extent they add to my personal burden. All of them in combination sure make me unhealthy :grumpy: An SNP that means nothing for someone healthy might be making me sicker.

    Of course I know my health problems can't be entirely blamed on my genes.

    Actually in an ideal world they would work wonderfully, just like for everybody else who is healthy with the same SNPs.... But the pharma, dental, agro and food industry have surely made things harder for me and my microbiome:bang-head:

    Thanks for chiming in here @WoolPippi :hug: your posts always make me learn a bit more about how to better deal with my health :angel:
     
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  9. Gondwanaland

    Gondwanaland Senior Member

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    Take this one for instance
    In 2011 I had 3 blood clots. The hematologist said my blood clots could not be blamed on this heterozygous SNP. He said more than half of the people walking right now on the streets are heterozygous for it as well.

    If you look to my other blood clotting factors they are all either +/- or -/-. My husband has one +/+ and never had a blood clot.

    Nevertheless, I had 3 blood clots o_O

    The dr. who made a dynamic ultrasound in my shoulders found out that I have a Thoracic Outlet Syndrome, and this was the cause to my blood clots, + taking the pill and a number of other unknown environmental issues.

    Also just recently I found out that a +/+MTHFR adds to excessive blood clotting. My husband is +/- for them.

    So each SNP is a piece of a single puzzle and I am the only person who can assemble it.
     
  10. Helen

    Helen Senior Member

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    Hi G-d,
    I would check if the DAO mutations could cause a lack of the DAO enzyme (that you luckily could add as a supplement). You can just try supplementing it before meals and see if it makes any change to the better. I don´t know more, just I want to alert you on this.

    ACE ++ You shouldn´t take ACE inhibitors

    Your heterozygot CYPs might have an effect on detoxification of meds.
    http://medicine.iupui.edu/clinpharm/ddis/main-table/

    You surely are aware of your probable need for methylfolate ;-). Just some thoughts after a quick look.
     
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  11. Gondwanaland

    Gondwanaland Senior Member

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    Thanks, Helen!
    It has been a dead end for me because there is something wrong with my uric acid metabolism. MFolate raises purines and I end up with metabolic acidosis :(

    As for the other ones you metioned, I have never really looked deeper into them. Thanks for the heads up :thumbsup:
     
  12. Helen

    Helen Senior Member

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    May I ask what tests you had to confirm this? I have high uric acid too for some reason.

    Adding DAO enzyme has been a real change for some people I know who had problems of unknown origin with foods. They just bought the supplement and tested and eureka their food intolerances vanished. If it always could be that simple....
     
  13. WoolPippi

    WoolPippi Senior Member

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    the liver! all kinds of bells starting to chime in tune here. :thumbsup:

    My liver is vulnerable, it's the first organ to struggle when I'm having stress.
    And I'm very sensitive to all kinds of little doses of things. Can be drugs, can be metals. (especially Al and Hg have a profound effect)
    The upside is I can test substances out with a tiny little amount, to find if it works. What nuggets have you discovered concerning these detox SNPs?

    remember that time that we didn't know this and both took mB12 by the handfull? :whistle:
     
  14. Helen

    Helen Senior Member

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    Maybe we shouldn´t hijack G-lands thread as this has been a special interest for me in the search for why some people get sick from amalgam and others don´t. Did you post your detox panel in any thread? If not, could you do that and I will try to answer your question.
     
  15. Gondwanaland

    Gondwanaland Senior Member

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    Unfortunately I only found a good nephrologist after healing myself at home. But my symptoms matched the description of metabolic acidosis while my kidneys still work perfectly. Apparently one will only be diagnosed with it at the ER if the kidneys are shutting down. My signals at the ER were:
    - low body temperature 34.6°C
    - serum sodium in the top range
    - serum potassium in the top range
    - creatinine normal in the middle of the range

    They sent me home and suggested I was having an anxiety attack. I have never been an anxious person.
    The following day I saw my hematologist and was able to convince him to give me an order to test for serum and urine magnesium. Serum Mg was in the top of the range and urine Mg very low below range. Then I knew I needed Mg, but at this point I had already tried glycinate, sulfate, citrate and aspartate with no success. Sometime later I decided to give Mg oxide a go and then all my acidosis symptoms quickly subsided, along with sodium bicarb baths.

    Then when I found a nephrologist who ordered all the proper tests (incl 24h urine) all my electrolytes were in mid-range, uric acid highish inside range, oxalate very low below range.

    So these are the only tricks I know to keep uric acid low: MgO + Na bicarb. Other people who tried it had problems with candida overgrowth :(

    So for now I put Mfolate in the back burner, because too much Mg lowered my Ca, and it is a snowball. I don't want to supplement with calcium. I have even restarted to eat dairy (yogurt, curd and cheese) to increase calcium input, since plant sources contain too much salicylates...

    The only foods I have been intolerant to are avocado and coconut oil, and by principle gluten, soy, nightshades (except for potatoes) and milk are out of my menu. So between taking another supplement or leaving avocados out, I leave avocados out. Unless if it could eliminate my constant bloating o_O

    Unfortunately I will have to live without imported supplements for now that my scholarship ended and currency conversion went crazy.

    Just like me!
    Just like me!
    I haven't found out much about them :meh:
    Exactly like me :jaw-drop: :hug: :love:
    Please do :thumbsup:
    I am very interested in that!
    Please tag me when you do that, ladies, as I don't want to miss this discussion :thumbsup:
     
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  16. Gondwanaland

    Gondwanaland Senior Member

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    :bulb:
    Yes, I read about that in my reports as well. In 2011 when I had the blood clots I spent the whole Easter holiday (total 4 nights) in the hospital taking heparin injections. And when I left I had a prescription for warfarin. From this episode onwards I could not sleep on the left side because of the blood clots on my left shoulder, and could not sleep on the right side due to a mysterious pain...
    I took warfarin for 1.5 years, but the specific pain on the right shoulder remained, plus a FM-like pain all over the body.

    After that I had some pain-free moments:
    - 1 year after having stopped the warfarin I went gluten-free, and all the pain was gone until I took some abx rounds and the pains came back
    - 6 months later I took my 1st sublingual MB12, and all pain was gone again, but came back after another med round
    - it just disappeared now that I upped my T3 and dropped the anti-depressant 2 weeks ago o_O

    OK, I finally got the message, my liver can't handle meds :bang-head:
     
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  17. Gondwanaland

    Gondwanaland Senior Member

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    Compiling some info regarding @Valentijn 's findings (thanks, Val!) :

    http://forums.phoenixrising.me/index.php?threads/interesting-cbs-variations.24492/

    rsID.........NAME....RISK...ETC
    rs121964968..L539S...GG....i5003392
    No SNPs matching 'i5003392' found in the data from your chip.

    rs6586282....G134A...CC...T is protective
    I am "no call" and DH is CC

    rs28934891...D444N...TT
    We are -/- CC

    rs28934892...P422L...A
    We are -/- GG

    rs121964967..K384E...CC...i5003393
    We are -/- TT

    rs121964972..T353M...A....i5003389
    We are -/- GG

    rs4920037....C530T...A
    We are -/- GG

    rs5742905....I278T...G
    We are -/- AA

    rs121964969..R266K...T....i5900470
    No SNPs matching 'i5900470' found in the data from your chip.

    rs234706.....C699T...GG...A is protective
    We are +/+ GG

    rs121964970..V168M...T....i5003391
    We are -/- CC

    rs121964963..P145L...A....i5003397
    We are -/- GG

    rs121964966..E144K...T....i5003394
    No SNPs matching 'i5003394' found in the data from your chip.

    rs121964964..A114V...A....i5003396
    We are -/- GG

    rs234709.....G477A...T
    I am +/- CT
    DH is -/- CC

    rs234715.....C224A...T
    We are -/- GG


    http://forums.phoenixrising.me/index.php?threads/interesting-bhmt-and-bhmt2-variations.24512/

    BHMT
    rsID.........NAME....RISK...ETC
    rs16876512...C4658T..CC...T is protective
    No SNPs matching 'rs16876512' found in the data from your chip.

    rs651852.....C6457T..CC...T is protective
    Both DH and I are +/- CT

    rs6875201....A7961G..AA...G is protective
    Both DH and I are +/+ AA

    rs7700970....C8721T..TT
    No SNPs matching 'rs7700970' found in the data from your chip.

    rs3797546....T1578C..CC
    Both DH and I are +/+ TT

    rs3733890....R239Q...A
    Both DH and I are +/+ GG

    BHMT2
    rsID.........NAME....RISK...ETC
    rs682985.....D54D....CC
    We are +/- CT

    rs625879.....A2010C..C....AA is protective
    We are +/- AC

    The SNP puzzle makes my head spin.
     
  18. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    AG

    AG

    CC

    The ones w/o my addition match your's. Maybe not twins, but maybe cousins;)
     
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  19. Valentijn

    Valentijn Senior Member

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    I think you got these two backwards. The alleles or genotypes listed are the risky ones, so you're -/- on both.

    If "G is protective" or similar is mentioned, it's because the riskier version is the most common version ... so having +/+ for those is just normal, rather than being an increased risk, and a few people get lucky and get the slightly faster -/- version.
     
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  20. ahmo

    ahmo Senior Member

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    @Valentijn maybe I can get a little more clarity with this example. The first one you quote, re TT, I also have. My snptips, when I mouse over that rs, says it's TT on the + strand.

    In the 2nd one, I'm AG on the + strand.

    You say, The alleles or genotypes listed are the risky ones.... Does this mean that all of the above are risky? That every time I look at my Promethease chart, or these rs numbers that become highlighted when I'm on a page listing those I have, these are always risky? I know I've tried to get this matter clear couple of times, so appreciate your explanation. thx
     

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