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Do Antihistamines improve your OI?

Discussion in 'Problems Standing: Orthostatic Intolerance; POTS' started by Aquila, Jun 10, 2013.

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Does your Orthostatic intolerance improve with antihistimines?

  1. I haven't taken them

    2 vote(s)
    15.4%
  2. no

    6 vote(s)
    46.2%
  3. they make me worse

    0 vote(s)
    0.0%
  4. a bit

    5 vote(s)
    38.5%
  5. alot

    0 vote(s)
    0.0%
  1. Aquila

    Aquila

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    I've read a lot about there being a third type of pots which is due to mast cell activation. It is possible that this type of pots would be helped by antihistamines. Benadryl (diphenhydramine) helps my Pots significantly. I've added a couple of links to papers in my next post.
     
  2. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    If you have an antihistamine that has sudafed in it, it should help OI as a vasoconstritor. It was one of the earliest meds prescribed.

    Sushi
     
  3. ukxmrv

    ukxmrv Senior Member

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    Sudafed does help me with OI but other antihistamines (like Benaryl make me sleepy only or have no effect).
     
  4. Aquila

    Aquila

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    This is one of the papers which talks about antihistamines helping.

    http://europace.oxfordjournals.org/content/13/3/306.full#ref-4
    http://hyper.ahajournals.org/conten...3e679af5223908c9a4acdbe4&keytype2=tf_ipsecsha
     
    charlie1 and camas like this.
  5. charlie1

    charlie1 Senior Member

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    @ Aquila, thanks for posting the articles.
    I find improvement in my dysautonomia symptoms (POTS and vasovagal sycompe) when taking sudafed.(decongestant)
    Lately I've added H1 and H2 (75 mg zantac am & pm and am Reactin) to my daily SR180 mg of Mestinon and .1mg florinef. I've done this to see if it might point to signs of me having MCA.
    The h1 and h2 addition has stopped my flushing episodes but unsure if I can attribute any OI benefits from it.
     
    camas likes this.
  6. Shell

    Shell Senior Member

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    Funny you should ask that. it's something I've been wondering about. I was thinking about experimenting on myself with Piriton to see if it would help the OI - which, bizarrely is much worse now I'm on Ivabradine. I came off the drugs for three days and saw no improvement so I thought I'd better get back on them.
    Still waiting and hoping for Hyper POTS tests ...
     
  7. xchocoholic

    xchocoholic Senior Member

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    My story ... When I started taking Zyrtec it helped my OI but then it stopped helping. I seem to do this with a lot of things tho. I suspect that I'm possessed by an evil spirit. :alien::lol: :)

    Benadryl knocks me out as does Vistaril and that's not good for orthostasis. And Sudafed dried me out too much.
     
  8. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    I don't have OI much. But diphenhydramine lessens polyuria (usually) for me, so that presumably should increase blood volume.
     
  9. IreneF

    IreneF Senior Member

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    Sudafed has always dried me out too much. Last time I took it, it made me so dizzy I had to go down the stairs one step at a time while clutching the rail.

    I take the antihistamine loratidine, aka Claritin, and it doesn't do a thing for OI or POTS. Benadryl knocks me out.
     
  10. Shell

    Shell Senior Member

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    This is an interesting question as I've been learning more about norepinephrine and dopamine. Being a slow and foggy person I hadn't twigged (embarrassingly) that norepinephrine is noradreneline. Once, what's left of my brain cells grasped that I did start to wonder if I should try antihists.
    What I can't help wondering though is, if histamine is being effected by low NorEp then why aren't more of us very allergic to stuff. I have a severe allergy to mango's and a mild allergy to oranges and orange juice (well, not that mild, it effects my breathing, but nothing else) and a mild dose of hayfever. If my OI was histo lack wouldn't I have more allergies?
    OTOH my OI is so bad at the moment it's worth a try.
     
  11. sandgroper

    sandgroper

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    my allergies appeared to improve as my other symptoms worsened but i think it was just that the allergies were manifesting differently
     
  12. xchocoholic

    xchocoholic Senior Member

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    Shell

    In my case it was because I didn't recognize that allergies present in a wide variety of ways.
    I was completely familiar with the runny nose and watery eyes reaction but not the others. If you look up allergic and non allergic reactions you'll find a long list. Vasodialation is one. Tc .. X
     
    sandgroper likes this.
  13. IreneF

    IreneF Senior Member

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    I have had more allergic reactions and sensitivities since I got sick.
     
  14. ukxmrv

    ukxmrv Senior Member

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    My allergies started with the acute onset viral ME. I do have a very allergic family though and many extended family members are as bad as I am. We also have ME in the extended family (and that includes inlaws)
     
  15. ABC

    ABC

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    if anything, benadryl lowers my blood pressure, haven't tried any other antihistamines
     
  16. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    There was something written last year or the year before from dr bell saying how he has found codeine helpful for pots/oi. Generally opiates vasodilate and then things like sudafed vasoconstrict, it seems confusing as to what will help. I suppose we dont know unless we try?? Sudafed (psuedoephedrine)itself isnt an antihistamine but an adrenergic stimulant in the same class as adrenaline etc.
     

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