Hi All, Looking to treat fatigue, cholesterol issues, dealing with gene mutations, etc I have become overwhelmed with information and continue to confuse myself on how to treat everything. I don't want to be locked into a practictioner that does testing and also pushes their supplements. I am trying to do most of this myself. Any input would be great! DNA Pathway planner (Mutations below) SHMT/C1420T +/- Hetero MTHFR/A1298C +/- Hetero MTRR/A66G +/- Hetero BHMT 1/2/4/8 +/- Hetero CBS/C699T and A360A +/- Hetero COMT/V158M +/+ A COMT/H62H +/+ T MAO A/R297R +/+ T Urine Amino Acids Test (Listing high/low only except ammonia which seems important) Methionine 5.5 (Range 9-56) low Lysine 36 (Range 45-700) low Taurine 1540 (Range 350-1850) high Ammonia 24000 (Range 12000-65000) Ok Glutamine 210 (Range 190-725) low Serine 170 (Range 140-568) low Beta-Alanine 37 (Range <35) high Anserine 290 (Range <110) high Carnosine 120 (Range <60) high Cystathione 6 (Range 9-65) low 1-Methylhistidine 500 (Range 80-450) high Alpha-Amino-N-Butyrate 5.7 (Range 8-90 Singulex Multipanel lab Uric Acid is at risk (Went up from last lab) Total Cholesterol is high, LDL high, HDL 67, APO B at risk Vitamin D >120 High Estradiol Low Homocysteine this lab 9, previous lab 13. B12 875 (Range >210) Folate 17.1 (Range >4.6) Cortisol ok (Presiously tanked out did supplementing in the past) Run 3-5 week Bulletproof coffee AM Eat fairly well High stress/Anxiousness once in a while. Listened to Dr. Ben Lynch a LOT and read the info from Dr. Amy Yasko that came with my pathway planner. Currently taking: MTHFRade (Electrolyte drink) Vitamin E Probiotic B1 Molybdenum Zinc B6 (P-5-P) Did B12 Methylcobalamin and 5-MTHF did seem like it helped. Also took Hydroxy as its supposed to be better for me because of my mutations. I felt REALLY anxious from it one day. So I stopped taking B12/Folate. Any input would be great! Thanks. Shane.