I have recently watched a conference about Lyme disease held in October at Icahn School of Medicine at Mount Sinai (New York). During the conference, prof. Kim Lewis (Northeastern University) talked about the persistent phenotype of Borrelia burgdorferi as a possible cause for at least some cases of post-treatment Lyme disease syndrome (PTLDS). He mentioned a drug (disulfiram) as a possible treatment for this condition. Disulfiram has been studied for Lyme disease only in vitro, so far (Pothineni V et al. 2016), but Kim Lewis mentioned a trial on the animal model of Lyme borreliosis, which is ongoing. You can follow his lecture in this video (from 39:00) and in this one (from 7:00). It is currently unknown how disulfiram exerts its action on Borrelia burgdorferi, but we know that in vitro it is able to kill persistent forms. My question is: has any of you tried this drug? It is curently used against alcoholism, as it is an inhibitor of the enzyme acetaldehyde dehydrogenase and thus it lets acetaldehyde build up, if you drink any alcohol, leading to unpleasent consequences.