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Disrupted brain circuitry for pain-related reward/punishment in Fibromyalgia. 1/2014 Arthritis Rheum

Discussion in 'Other Health News and Research' started by *GG*, Feb 17, 2015.

  1. *GG*

    *GG* Senior Member

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    Concord, NH
    CONCLUSION:
    FM patients exhibit disrupted brain responses to reward/punishment. The ventral tegmental area is a source of reward-linked dopaminergic/γ-aminobutyric acid-releasing (GABAergic) neurotransmission in the brain, and our observations are compatible with reports of altered dopaminergic/GABAergic neurotransmission in FM. Reduced reward/punishment signaling in FM may be related to the augmented central processing of pain and reduced efficacy of opioid treatments in these patients.

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