*GG*
senior member
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- 6,389
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- Concord, NH
CONCLUSION:
FM patients exhibit disrupted brain responses to reward/punishment. The ventral tegmental area is a source of reward-linked dopaminergic/γ-aminobutyric acid-releasing (GABAergic) neurotransmission in the brain, and our observations are compatible with reports of altered dopaminergic/GABAergic neurotransmission in FM. Reduced reward/punishment signaling in FM may be related to the augmented central processing of pain and reduced efficacy of opioid treatments in these patients.
Copyright © 2014 by the American College of Rheumatology.
Comment in
FM patients exhibit disrupted brain responses to reward/punishment. The ventral tegmental area is a source of reward-linked dopaminergic/γ-aminobutyric acid-releasing (GABAergic) neurotransmission in the brain, and our observations are compatible with reports of altered dopaminergic/GABAergic neurotransmission in FM. Reduced reward/punishment signaling in FM may be related to the augmented central processing of pain and reduced efficacy of opioid treatments in these patients.
Copyright © 2014 by the American College of Rheumatology.
Comment in
- What is the proper control group for a fibromyalgia study? Comment on the article by Loggia et al. [Arthritis Rheumatol. 2014]
- Reply: To PMID 24449585. [Arthritis Rheumatol. 2014]