I just wanted to discuss this as it was brought up in another thread and i thought it was interesting. This info is from wikipedia but its just the basics. Half of all 5 y/o children in the USA carry ebv and 90-95% of adults carry ebv. Ebv causes mono in teenages 35-50% of the time. Im guessing other viruses like cmv cause mono the other viruses that cause mono. EBV infects b-cells. The name chronic ebv was brought up for a name of cfs, my opinion was that it probably wasnt that far off. It possibly could be a triggering virus in cfs/me and then it might not be but it could be reactivated later on and cause issues. Most cfsers have low nk function, these nk cells help protect us from viruses and reactivated viruses, so having a low nk function can make us prone to ebv reactivation. They are also finding that ebv causes issues with b-cells in cfs which could how rituximab works??? Myself as an example, i tested positive to ebv after a case of mono which was one of the viruses i had that triggered cfs for me. Several years later i tested totally negative to ebv. Generally when one gets ebv they produce igg antibodies that one then produces for life through the b cells and suppose to protect us from further infections, suppose to. Now what i found when i read Oslers web was that many from the outbreaks in the 1980s of cfs initially tested positive to ebv with igg life long antibodies but then some years later lost these life long antibodies for some reason, not everyone but a significant group did. I thought maybe this was what happened to me. This is all my reasoning but if someone with cfs/me tests totally negative to ebv then they are either in that 5-10% of adults who never got ebv or more likely were similar to the cfsers who stopped making ebv igg antibodies. This doesnt mean they dont have the virus but more so that there immune system/ b cells arent producing antibodies to protect them from ebv. Now if one has low nk function and other indications of immune supression like most cfs/me people then ebv and other viruses are going to be more prone to ebv reactivating. Why doesnt everyone improve when treating ebv with antivirals?? Dr Petersons research shows a high percentage also have cmv and hhv6 and or have bacterial co-infections that would mask any improvement made from lowering of ebv, although some people do notice some improvement as it would take a load off the immune system. Im posting this more as a debate and to show that with the research they had in the 1980s that chronic ebv probably wasnt far off the mark and alot better name then cfs. ebv reactivation commonly occurrs in immune supressed people with HIV or organ transplant patients on immunosupressive therapy, so i think this also shows the cfs/me has a significant amount of immunosupression going on. Even if someones cfs trigger was a vaccine, this lowering of immunity could make one more prone to having these viruses like ebv reactivate. I just think it shouldnt be something overlooked. Look forward to hearing others opinions on this as well as from other people who have tested positive to ebv and think they also have lost antibodies to ebv or other viruses. cheers!!