Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Discovery of Structurally Diverse Small Molecule Compounds with Broad Antiviral Activity Againts Ent

Discussion in 'General ME/CFS News' started by Never Give Up, Feb 8, 2016.

  1. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

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    Gemini likes this.
  2. Gingergrrl

    Gingergrrl Senior Member

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    @Never Give Up I looked at the article but was wondering if you could explain it for non-sciency people like me! Is there an anti-viral for enteroviruses now? I actually have my consultation with Dr. Chia later this week so it is great timing. I was positive for two EV's one year ago but do not yet know what my recent tests show and will find out this week at my appt. I guess if they are negative it will not matter but if they are still positive, is there a treatment now?
     
  3. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

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    UCLA researchers found a variety of compounds that inhibit the Enterovirus Coxsackie B3 from multiplying inside cells. The same compounds demonstrated antiviral activity against a number of other Enteroviruses. This opens up a whole new world of antienteroviral drug development.

    We currently have combinations of medications which do go after Enteroviruses, but these new compounds look to be much more powerful and targeted than what we have now.

    When is your appointment with Dr. Chia?
     
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  4. Gingergrrl

    Gingergrrl Senior Member

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    Thanks for clarifying the article and I sent you a PM re: appt with Chia.
     
    Never Give Up likes this.
  5. Kati

    Kati Patient in training

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    To be realistic, the time between this discovery and approval by FDA will be measured in years. This compound would need to be tested for safety, dosage, efficacy through clinical trials.
     
  6. Gingergrrl

    Gingergrrl Senior Member

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    @Kati I totally agree but at least it seems hopeful that researchers are working on discovering a treatment for EV's at all. I have no idea if this will ever pertain to me but am hoping it helps many people in the future.
     
  7. Gemini

    Gemini Senior Member

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    Very much agree. Thanks to @Never Give Up for posting this interesting paper.

    How researchers performed high-throughput screening of 85,000 compounds leading to their selection of 11 for further study:

    http://mbioblog.asm.org/mbiosphere/2016/01/new-promise-for-treatment-of-enterovirus-infections.html

    At the UCLA Lab besides their search for treatments, Susan Wollersheim's research into "dual rhinovirus/enterovirus" infections sounds intriguing:

    www.uclahealth.org/provider/paul-krogstad-md

    Nice that Dr. Chia is nearby!
     
    Last edited: Feb 21, 2016
    Never Give Up likes this.
  8. Gingergrrl

    Gingergrrl Senior Member

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    The appt was not helpful for me but we are all different and I would never discourage anyone else from going this route.
     

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