Discovery of Structurally Diverse Small Molecule Compounds with Broad Antiviral Activity Againts Ent

[Never Give Up]

The last word in the title is Enteroviruses, not enough space.

Interesting progress:

http://aac.asm.org/content/early/20...=fh/6KnAyqSvMU&keytype=ref&siteid=asmjournals

 

[Gingergrrl]

@Never Give Up I looked at the article but was wondering if you could explain it for non-sciency people like me! Is there an anti-viral for enteroviruses now? I actually have my consultation with Dr. Chia later this week so it is great timing. I was positive for two EV's one year ago but do not yet know what my recent tests show and will find out this week at my appt. I guess if they are negative it will not matter but if they are still positive, is there a treatment now?

 

[Never Give Up]

UCLA researchers found a variety of compounds that inhibit the Enterovirus Coxsackie B3 from multiplying inside cells. The same compounds demonstrated antiviral activity against a number of other Enteroviruses. This opens up a whole new world of antienteroviral drug development.

We currently have combinations of medications which do go after Enteroviruses, but these new compounds look to be much more powerful and targeted than what we have now.

When is your appointment with Dr. Chia?

 

[Gingergrrl]

Thanks for clarifying the article and I sent you a PM re: appt with Chia.

 

[Kati]

To be realistic, the time between this discovery and approval by FDA will be measured in years. This compound would need to be tested for safety, dosage, efficacy through clinical trials.

 

[Gingergrrl]

@Kati I totally agree but at least it seems hopeful that researchers are working on discovering a treatment for EV's at all. I have no idea if this will ever pertain to me but am hoping it helps many people in the future.

 

[Gemini]

@Kati I totally agree but at least it seems hopeful that researchers are working on discovering a treatment for EV's at all. I have no idea if this will ever pertain to me but am hoping it helps many people in the future.

Very much agree. Thanks to @Never Give Up for posting this interesting paper.

How researchers performed high-throughput screening of 85,000 compounds leading to their selection of 11 for further study:

http://mbioblog.asm.org/mbiosphere/2016/01/new-promise-for-treatment-of-enterovirus-infections.html

At the UCLA Lab besides their search for treatments, Susan Wollersheim's research into "dual rhinovirus/enterovirus" infections sounds intriguing:

www.uclahealth.org/provider/paul-krogstad-md

Nice that Dr. Chia is nearby!

 

[Gingergrrl]

Nice that Dr. Chia is nearby!

The appt was not helpful for me but we are all different and I would never discourage anyone else from going this route.