Generalized Anxiety Disorder Murray B. Stein, M.D., M.P.H., and Jitender Sareen, M.D. N Engl J Med 2015; 373:2059-2068November 19, 2015 I think that this piece is related to a recent diagnostic quiz in the journal, which alarmed but did not entirely surprise me in that it offered a list of psychiatric diagnoses but not a single physiological one. It makes several claims for 'evidence', based on research that I suspect is of poor quality as it sounds oh-so-familiar. This conflict of interest is given at the end: Some other quotes that cause me to question the validity of the claims and general psychiatric gist of the piece are: Er, where are the mental illnesses in that lot? Actually this seems to me to be more of a typical issue with doctors, who are unable to say "I don't know." Perhaps they project this onto their patients - this is claimed to be a common psychological problem - mistaking your psychological problems/fears as being someone else's! Isn't worrying excessively the definition of GAD? The reference to chronic gastrointestinal symptoms is a big clue IMO, which is not adequately addressed in this article. Having personally reduced my anxiety levels dramatically through diet and supplements, and read of others who have done the same, it seems extremely remiss for the authors not to mention this. Has it not yet filtered through to such a respected journal as the NEJM? Instead they are allowing an article that promotes the usual dubious 'evidence' and the usual treatments, which have very limited efficacy IME and IMO, and some can be dangerous. So why should it be encouraged? Shades of PACE here... When I was an anxiety-ridden child there were no computers and very little on TV. My time was spent making my own entertainment, which included country walks. I did, however, have gastrointestinal problems and a diet full of sugar and starch. Did children only start getting GAD when computers and smartphones were invented? I don't think so. The authors say it's OK. So that's all right then. Really? I haven't heard about this, but have heard about increasing evidence for SSRIs increasing suicidality, amid withholding of data about this risk. I think it involves unpublished studies.