CFS/ME shares several common points with hypothyroism (and also with Autism subgroup), such as impairment of mytochondrial efficacity and consecutive increased lactatemia when more energy is needed (both in the blood and in the brain)... I happened to learn that my mother (also concerned by CFS/ME) carries one copy of the C allele on the rs225014 gene. (mutation that can impair the efficacity of the DIO2) I have not tested my genome yet, but I wonder if some of you have this test done? About the DIO2 polymorphism on rs225014: "The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues." https://www.ncbi.nlm.nih.gov/gene/1734 it may be important for us to know our genetic status on this gene, because we all try L Carnitine as a supplement, and is is known to interfere with thyroid function: "By experiments on cells (neurons, hepatocytes, and fibroblasts) that are targets for thyroid hormones and a randomized clinical trial on iatrogenic hyperthyroidism, we validated the concept that L-carnitine is a peripheral antagonist of thyroid hormone action. In particular, L-carnitine inhibits both triiodothyronine (T3) and thyroxine (T4) entry into the cell nuclei." https://www.ncbi.nlm.nih.gov/pubmed/15591013 I also have TPO antibodies, so I wonder if Carnitine is really acurate for me... TPO antibodies are very common antibodies, I wonder if they are more or less frequent in our CFS/ME community?