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Difficulty with Freddd protocol (anxiety)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Rayski2, Nov 27, 2015.

  1. Rayski2

    Rayski2

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    Hello everyone,

    I've been on freds methylation protocol for the last 2 weeks and getting alot of anxiety that seems dose dependent with the Methyl b12. Here is my log so far with notes ;

    Nov 19
    100mcg mb12
    100mcg metafolin

    Nov 20
    150mcg mb12
    Depressed at night

    Nov 21
    9am 250mcg mb12
    1pm 250mcg
    8pm depressed

    Nov 22 1000mcg mb12
    10am 500mcg methyl b12
    10am 100mcg metafolin
    1230pm 250mcg mb12
    440pm 250mcg mb12
    TOO MUCH
    8pm Anxiety, heart racing, needed xanax .25mg

    Nov 23
    720am 250mcg mb12
    400mg potassium
    3pm 250mcg mb12
    400mg potassium
    442pm little headache
    150mg potassium

    Nov 24
    8am 200mcg metafolin
    8am 250mcg mb12
    230pm 250mcg mb12
    7pm little speedy seems like threshold dose

    Nov 25
    100mcg metafolin
    250mcg mb12
    250mcg mb12


    Nov 26
    10am 250mcg mb12
    150mcg metafolin
    4pm 250mcg mb12

    Nov 27
    10am 200mcg metafolin
    10am 250mcg mb12
    4pm 250mcg mb12

    Any advice? Thanks ahead of time,
    Ray
     
  2. SB_1108

    SB_1108 Senior Member

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    Have you had your 23andme genetic mutations analyzed? You may not tolerate methyls well...
     
  3. Rayski2

    Rayski2

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    I have not had it tested and can't afford it now that it's 200$. All I'm going by is my history and some blood tests. I took high dose injection cyanocobalamin and NAC and a multivitamin with folic acid for years. As for blood tests i had high Homocysteine 11.4(<11.3), high Hemoglobin and high b12 1200 but still had low b12 symptoms. I've stopped NAC only 2 weeks ago and believe my issue was due to my history with those supplements rather than MTHFR. But who knows
     
  4. SB_1108

    SB_1108 Senior Member

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    Can you swap out your methylcobalamin and try hydroxocobalamin?
     
  5. minkeygirl

    minkeygirl But I Look So Good.

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    Niacin will stop methylation and the anxiety. I got it from too high metafolin

    Forget the docs website. MTHFR help I think he talks about This exact thing.

    In here.

    http://mthfr.net/
     
  6. Rayski2

    Rayski2

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    I can try that, I was following Freddd's protocol I don't remember what he said about hydroxo but doesn't it not convert for a lot of people? Damn brain fog can't remember anything anymore :/


    I popped 1000mg niacinamide that somewhat helps but not enough. Xanax is the only thing that really gets rid of the anxiety from it. Is there a way to tag Freddd on here to see what he thinks? I don't know if I should raise metafolin or lower mb12 or what I'm so confused
     
  7. minkeygirl

    minkeygirl But I Look So Good.

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    You have to keep taking it. About 100 mgs every hour. The flushing kind till it eases.

    Back down on everything and start over. Imo. If the balance is off you have to figure that out.


    @Freddd @PeterPositive @Martial @ahmo might be able to help
     
  8. Rayski2

    Rayski2

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    I see, I do have a bottle of that kind I'll try it. And for when any of the tagged users see this I'm also hypothyroid and not sure if I should get that under control before starting the b12 and folate or if those deficiencies can cause hypothyroid? No idea what I'm doing and I've read almost all of fred's posts
     
  9. minkeygirl

    minkeygirl But I Look So Good.

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    It's very complicated. I couldn't do it. You have to start very low and very slow. That I know.

    Niacin will stop the methylation. Get stable before you start again. This is not a race.
     
  10. Rayski2

    Rayski2

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    Sounds good. Is it unhealthy to just stop the methylation supps? Since it's starting a healing reaction then stopping the supps to support it?
     
  11. minkeygirl

    minkeygirl But I Look So Good.

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    Don't know. I'm clueless but having intolerable anxiety isn't so great either. That's not healing.

    Maybe just drop down really low until someone here can advise you.

    Like I said. I stopped because it was too complicated for me and when I did manage to do it for a short time I got no benefit

    B's are very complicated

    Look in Ahmo's signature. I think she had s methylation for dummies link.
     
  12. ahmo

    ahmo Senior Member

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    I don't think you need to fix your thyroid first. I don't know whether these deficiencies cause low thyroid, I don't think so.

    Niacin slows down reactions from folate, but you say you're having problems w/ B12. When I look at your list, the place where you list speedy is the day when you took 200mcg folate. Folate is generally the thing that causes anxiety. I'm afraid I can't offer any suggestions. I've compiled many of Fred's comments in a Guide to Freddd's Protocol, the 2nd link in my signature.
     
  13. SB_1108

    SB_1108 Senior Member

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    Thats kinda my story. The anxiety was intolerable. I saw some benefit so I take it less often.

    The 23andMe test would help you determine whether you need Hydroxy or Methyl because of conversion issues.
     
  14. minkeygirl

    minkeygirl But I Look So Good.

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    @caledonia has a link with some great info about this in her signature. Helped me a lot

    I have several "double whammys".
     
  15. TheChosenOne

    TheChosenOne Senior Member

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    I used to have high anxiety when taking high doses of methylB12.
    I tried some niacin, which worked great. But in the long run, it made me depressed. So I stopped doing that.
    Then I tried GABA supplements. Those worked a bit (even it doesn't cross the blood brain barrier), but it wasn't all that effective.
    Magnesium was also slightly beneficial, but the gains were very minor.
    Then I tried lithium, because it can lessen mood swings and possibly also anxiety. This worked better than the previous things I tried, but even this wasn't ideal. If I took it for too long, it would make me sad.
    Then @ahmo commented on my post about bipolar mentioning pyrrole disorder. It depletes B6 and zinc, causing depression, mood swings, digestive problems, anxiety, ... So, I started taking my B complex again. This didn't remove anxiety, even tho I felt calmer on it.
    I ordered p5p (active form of B6) and the difference is massive. All anxiety is gone which is amazing. I can take 1300 mcg methylB12 and 600 mcg folate without any problems now.
    I still need to do a pyrrole test.

    PS: I always had anxiety, even before supplementation.
     
    Mary and ahmo like this.
  16. Rayski2

    Rayski2

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    3 days off everything and taking niacin all day and my anxiety isn't getting better i dont know what to do..

    Glad you fixed your anxiety. Is tried all the pyrolle supps and they didn't do anything. I had a test done too and i dont have pyroluria.
     
  17. ahmo

    ahmo Senior Member

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  18. Rayski2

    Rayski2

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  19. sregan

    sregan Senior Member

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    I noticed you only took Potassium on one of your days. I've found it to be calming when I am taking DQ supps and I sleep much better when I've taken mine for the day.
     
  20. Rayski2

    Rayski2

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    Oops sorry on that log I meant extra potassium in addition to the 500mg i take morning and night on an empty stomach
     

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