Hello, Methylation start up sure is tricky isn't it? I've been at it for awhile on the deadlock quartet, plus lectithin, zinc, magnesium, bcaas. Started low, going slow. I also am slowly tapering hyrdrocortisone down, and titrating pregnenolone and DHEA to compensate and hopefully retrain a blunted HPA axis. However, since bumping up b12 to 2000ish (divided by two in the morning) and solgar metafolin to 1200 (divided by three throughout the day), I feel hit by a truck. Flu-like achiness and exhaustion. Migraines. This is coinciding with a nasty sinus long lasting infection. Do others find it hard to distinguish symptoms of methylation from other possible causes? Particularly, normal dips in energy from flu season, and more interestingly, as a woman, from hormonal fluctuations, such as what comes with trying to balance hormones and other factors such as endometriosis, and blunted HPAGPA axis?