Thanks for your answer @ArunP ! Haven't been able to find anything that clears this "lump/tightness" thing for me, and it is driving me absolutely insane and making my life miserable. Thankfully, it is better than a week ago, but far from good. I do believe mine is mostly, or maybe all, neuro-muscular related i.e. spasms, tightness, weakness. It feels like that anyway, that it is the muscles. It hurts and "tightens" a lot in my throat. Of course my chest and abdominal muscles also become severly fatigued from this type of breathing. I try and breath a lot through my nose as you describe, and it alleviates it a little actually. I also sometimes have trouble swallowing, but haven't noticed any connection to the breathing thing. It does not worsen at the same time as I have noticed anyway. I have tried two different medications for asthma which did nothing, so my problem is not there. I am actually on clonazepam daily now because I read that it could help "all" of my ME symptoms, but unfortunately did nothing for me. I am weening off it very slowly now as I don't want to be on a medication that doesn't work. I am already on enough drugs ;-). Will ask my M.E. doctor if I can try a muscle relaxant next time I see him, to see if that helps, or if he has any other suggestions. Please do keep me updated if they find anything! As I have said, I have had this off and on since I got ME almost 9 years ago. I really don't want to go through more specialist appointments if I can avoid them, as I feel I have seen every one of them multiple times.