Hi there! I am following the GAPS diet to help resolve severe leaky gut and fructose malabsorption. My doc thought it beneficial to test for MTHFR as well due to the bone-crushing fatigue I've been dealing with for the last few months. I tested positive for the C677T mutation (homozygous) but my B12 levels were within range (564). My doctor advised me to start this supplement: https://www.xymogen.com/products/product-detail.aspx?pid=122 So I started it this last weekend. I also got a massage on Sunday and my masseuse found a knot in my back. She's fairly certain it's just a very deep muscular knot, but is a little worried that it might be inflammation in my kidneys. Over this week I've had some worrisome symptoms develop and think they are either due to die-off with the new supplement or might indeed have something to do with my kidneys: I have horrible flank pain/soreness, headaches, leg cramps, sharp pain in legs when walking, back pain (started out lower only, now both upper and lower back are sore), severe nausea, my feet/ankles are swelling so bad I can barely get shoes on and every now and then I'm getting a weird, sharp shooting pain in my left forearm from my elbow to my wrist. I have Lyme Disease (in remission) so I'm pretty familiar with herxing/die-off and I'm a bit worried as some of these things aren't typical to what I know of die-off. So I just thought I'd reach out to some of you who are more experienced with MTHFR treatment. Could these symptoms be die-off from the Methyl Protect? I cut back to only 1/3 a capsule but I'm still feeling all the symptoms full tilt. I'm calling my doctors office first thing on Monday (they're closed today) to notify them of the new symptoms but in the meantime any input would be greatly appreciated!